Non-steroidal progesterone receptor specific ligands.

Keywords: steroid receptors, abortion, knockout mice, pr-b isoform, breast cancer, progestin antagonists, carbamate, tetrahydrobenzindolone Mini-Reviews in Medicinal Chemistry Title: Non-Steroidal Progesterone Receptor Specific Ligands Volume: 5 Issue: 8 Author(s): G. F. Allan and Z. Sui Affiliation:

steroid receptors, abortion, knockout mice, pr-b isoform, breast cancer, progestin antagonists, carbamate, tetrahydrobenzindolone

The nuclear receptor for progesterone is a target for contraception and for several therapeutic indications. Progestin agonists and antagonists in clinical use mimic the steroidal backbone of the cognate ligand, progesterone. Thus, they have significant cross-reactivity with other steroid receptors. Recently, nonsteroidal progesterone receptor ligands have begun to appear in the literature. This review will describe the current status of research into these promising new chemical entities. Export Options About this article Cite this article as: Allan F. G. and Sui Z., Non-Steroidal Progesterone Receptor Specific Ligands, Mini-Reviews in Medicinal Chemistry 2005; 5 (8) . https://dx.doi.org/10.2174/1389557054553794 | DOI https://dx.doi.org/10.2174/1389557054553794 | Print ISSN 1389-5575 | | Publisher Name Bentham Science Publishers | Online ISSN 1875-5607 | Call for Papers in Thematic Issues Advanced Polymeric Systems in Medicinal Chemistry and Drug Delivery Recent advances in medicinal chemistry have increasingly integrated polymer science to address longstanding challenges associated with conventional therapeutics, including poor aqueous solubility, rapid systemic clearance, off-target toxicity, limited bioavailability and as am active agent also. 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