The use of stem cells for treatment of premature ovulation failure and generation of oocytes

Dania H Al Jaroudi, Dalia Ali
In: Obstetrics & Gynecology International Journal · 2018 · vol. 9(6) · doi:10.15406/ogij.2018.09.00384 · W2603184942
article OA: bronze CC0 ⤵ 1 in-corpus citation
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Abstract

Background: Premature Ovarian Failure (POF) is a life-changing condition that affects 1% of women under the age of 40. POF is also known as premature menopause, and hyper gonadotropic hypogonadism; POF can be primary (spontaneous) or secondary which is usually induced by radiation, chemotherapy or surgery. It comprises of amenorrhea, high menopausal levels of gonadotropin and sex steroid deficiency. The use of mesenchymal stem cells in treatment of POF has been reviewed using different sources of MSCs of umbilical cord, bone marrow transplantation, amniotic fluid and adipose tissue. Many authors have highlighted the importance of re-establishment of hormone or cytokine profiles supporting stem cell follicular development is crucial for the improvement of both the damaged ovary function and fertility recovery.

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