Effect of peritoneal washings from women with endometriosis on sperm velocity.
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Peritoneal washings from women with endometriosis significantly impaired sperm velocity and motility during in vitro capacitation compared to washings from fertile women.
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Abstract
In a prospective study the author measured the "before" and "after" effects of in vitro washing and capacitation on sperm characteristics in 25 normospermic men using a microcomputerized system for semen analysis. Each fresh semen sample was divided into aliquots and assigned to one of four groups: group I--untreated sperm; group II--sperm capacitated with Ham's F-10 medium enriched with 20% decomplemented human serum (HHS); group III--sperm capacitated with HHS to which had been added 10% peritoneal washings in 5% dextrose and lactated Ringer's injection obtained from women of proven fertility at the time of laparoscopic tubal ligation; and group IV--sperm capacitated with HHS to which had been added 10% peritoneal washings in D5RL obtained from women with endometriosis (American Fertility Society stages I and II) diagnosed at the time of diagnostic laparoscopy. Semen characteristics, including sperm velocity, percent motility and motility index, in group II were all significantly improved over those in group I. The addition of peritoneal washings to the capacitation medium (group III) did not further improve the indices except for percent motility, which was significantly increased over that in group II (P less than .01). The addition of peritoneal washings from women with proven endometriosis to the capacitation medium, however, had a marked and statistically significant (P less than .0001) detrimental effect. These results suggest that the adverse effect of endometriosis on fertility may be biochemically mediated.
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Cited by (20)
- Endometriosis 2015
- Endometriosis 2010
- Immunology and Endometriosis 2003
- Effect of peritoneal fluid from endometriosis patients on sperm motion characteristics and acrosome reaction. 1999
- Pathophysiology of Endometriosis-Associated Infertility 1999
- Peritoneal fluid modulates the sperm acrosomal exocytosis induced by N-acetylglucosaminyl neoglycoprotein 1999
- Immunology of endometriosis 1999
- The effects of follicular fluid from patients with different indications for IVF treatment on the binding of human spermatozoa to the zona pellucida 1998
- Effects of Antibodies to Transferrin and Alpha 2‐HS Glycoprotein on In Vitro Sperm Motion: Implications in Infertility Associated with Endometriosis 1998
- Effect of Peritoneal Fluid on Sperm Motility Parameters in Women with Endometriosis 1997
- Endometriosis-associated infertility 1997
- The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro 1996
- The peritoneal environment in endometriosis 1996
- Peritoneal fluid from women with moderate or severe endometriosis inhibits sperm motility: the role of seminal fluid components 1996
- Pathogenesis of Infertility in Endometriosis 1995
- Endometriosis: Immune Cells and Their Products 1994
- An elicited intraperitoneal inflammatory response has no effect on the establishment of pregnancy in the mouse 1994
- Effects of peritoneal fluids from patients with endometriosis on capacitated spermatozoa 1993
- 8 Endometriosis-associated infertility 1993
- The Lack of Effect of Tumor Necrosis Factor‐Alpha, Interleukin‐1‐Alpha, and Interferon‐Gamma on Human Sperm Motility In Vitro 1992
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