CLINICAL AND ANAMNESTIC CHARACTERISTIC OF PATIENTS WITH ENDOMETRIAL HYPERPLASTIC PROCESSES AND ASSESSMENT OF LEPTIN EXPRESSION

Objectives. To study the clinical manifestations of endometrial hyperplastic processes and leptin expression using immunohistochemical method. Material and methods. The study included 117 patients, the main group consisted of 67 women of reproductive age with endometrial hyperplastic processes, the comparison group was composed of 50 patients with histologically normal endometrium. The expression of leptin in the endometrium was studied in all patients. Results. The main clinical manifestation of endometrial hyperplastic processes is spotting bloody discharge not associated with menstruation, which occurs in 11 (16.42%) patients, in the comparison group – in 1 (1.27%), (χ2=6.47; p=0.01). To determine indications for the way of histological verification of endometrial pathology, it should be considered that the sensitivity of the routine ultrasound diagnostic method is 82.09%, its specificity is 78.00%, which combined with the absence of specific clinical manifestations makes the disease diagnosing difficult. Сomparing the body mass index of patients, the incidence of obesity and overweight no significant differences were observed between both groups. However, in patients of the main group the expression of leptin in the endometrium was significantly lower and made up 25.20 (22.00; 27.30), in the comparison group – 27.20 (24.20; 32.00) (z=2.14, p=0.03). Conclusions. The results obtained demonstrate a decrease of leptin expression in patients with endometrial hyperplastic processes.