CLINICAL AND ANAMNESTIC CHARACTERISTIC OF PATIENTS WITH ENDOMETRIAL HYPERPLASTIC PROCESSES AND ASSESSMENT OF LEPTIN EXPRESSION

Yu. A. Lyzikova
In: Vestnik of Vitebsk State Medical University · 2024 · vol. 23(1) , pp. 34–39 · doi:10.22263/2312-4156.2024.1.34 · W7161629151
article OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-13 ⓘ

This study assessed endometrial hyperplastic processes in 117 women, finding that patients exhibited significantly lower leptin expression in the endometrium compared to those with normal endometrium.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-13 · read from full text ⓘ

This study evaluated the clinical characteristics and leptin expression in 117 women, comparing 67 patients with endometrial hyperplastic processes against a control group of 50 individuals with histologically normal endometrium. The researchers found that intermenstrual spotting was a significant clinical manifestation in the patient group and determined that routine ultrasound had moderate sensitivity and specificity for diagnosis. Notably, immunohistochemical analysis revealed significantly lower leptin expression levels in the endometrium of patients with hyperplastic processes compared to those with normal tissue. This paper is centrally about endometriosis — specifically, it investigates endometrial pathology markers often associated with conditions like adenomyosis and endometriosis, though the primary focus remains on hyperplasia rather than ectopic implantation.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Objectives. To study the clinical manifestations of endometrial hyperplastic processes and leptin expression using immunohistochemical method. Material and methods. The study included 117 patients, the main group consisted of 67 women of reproductive age with endometrial hyperplastic processes, the comparison group was composed of 50 patients with histologically normal endometrium. The expression of leptin in the endometrium was studied in all patients. Results. The main clinical manifestation of endometrial hyperplastic processes is spotting bloody discharge not associated with menstruation, which occurs in 11 (16.42%) patients, in the comparison group – in 1 (1.27%), (χ2=6.47; p=0.01). To determine indications for the way of histological verification of endometrial pathology, it should be considered that the sensitivity of the routine ultrasound diagnostic method is 82.09%, its specificity is 78.00%, which combined with the absence of specific clinical manifestations makes the disease diagnosing difficult. Сomparing the body mass index of patients, the incidence of obesity and overweight no significant differences were observed between both groups. However, in patients of the main group the expression of leptin in the endometrium was significantly lower and made up 25.20 (22.00; 27.30), in the comparison group – 27.20 (24.20; 32.00) (z=2.14, p=0.03). Conclusions. The results obtained demonstrate a decrease of leptin expression in patients with endometrial hyperplastic processes.
Full text 5,638 characters · extracted from oa-html · 3 sections · click to expand

Material

and methods. The study included 117 patients, the main group consisted of 67 women of reproductive age with endometrial hyperplastic processes, the comparison group was composed of 50 patients with histologically normal endometrium. The expression of leptin in the endometrium was studied in all patients. Results. The main clinical manifestation of endometrial hyperplastic processes is spotting bloody discharge not associated with menstruation, which occurs in 11 (16.42%) patients, in the comparison group – in 1 (1.27%), (χ2=6.47; p=0.01). To determine indications for the way of histological verification of endometrial pathology, it should be considered that the sensitivity of the routine ultrasound diagnostic method is 82.09%, its specificity is 78.00%, which combined with the absence of specific clinical manifestations makes the disease diagnosing difficult. Сomparing the body mass index of patients, the incidence of obesity and overweight no significant differences were observed between both groups. However, in patients of the main group the expression of leptin in the endometrium was significantly lower and made up 25.20 (22.00; 27.30), in the comparison group – 27.20 (24.20; 32.00) (z=2.14, p=0.03). Conclusions. The results obtained demonstrate a decrease of leptin expression in patients with endometrial hyperplastic processes.

Keywords

leptin, endometrial hyperplastic processes. Financing. The study was sponsored by the Innovation fund of the Gomel Regional Executive Committee (State Registration No. 20201765, 05.11.2020).

References

1. Kravchenko EN, Lautenshleger EV. Endometrial hyperplasia and endometrial polyps: clinical and anamnestic characterization of women. Fundam Klin Meditsina. 2023;8(4):16-23. (In Russ.) 2. Dokter E, Anderson L, Cho SM, Cohen-Hallaleh V, Lam KM, Saidi SA, et al. Radiology-pathology correlation of endometrial carcinoma assessment on magnetic resonance imaging. Insights Imaging. 2022 Apr;13(1):80. doi: http://dx.doi.org/10.1186/s13244-022-01218-3 3. Shvarev EG, Dikareva LV, Zoeva AR, Tishkova OG, Zaytseva OE, Ukhanova YuYu. Hyperplastic processes in the endometrium: controversial and unsolved problems of the disease. Ros Vestn Akushera-ginekologa. 2023;(4):35-43. (In Russ.) 4. Méndez-López LF, Zavala-Pompa A, Cortés-Gutiérrez EI, Cerda-Flores RM, Davila-Rodriguez MI. Leptin receptor expression during the progression of endometrial carcinoma is correlated with estrogen and progesterone receptors. Arch Med Sci. 2017 Feb;13(1):228-235. doi: http://dx.doi.org/10.5114/aoms.2017.64721 5. Ryzhov YuR, Shpakov AO, Gzgzyan AM. The role of leptin in the regulation of the reproductive system and prospects for its use in assisted reproductive technologies. Problemy Reproduktsii. 2020;26(2):53-61. (In Russ.). doi: http://dx.doi.org/10.17116/repro20202602153 6. Su S, Yin L. Application of Pelvic Magnetic Resonance Imaging Scan Combined with Serum Pyruvate Kinase Isozyme M2, Neutrophil Gelatinase-Associated Lipocalin, and Soluble Leptin Receptor Detection in Diagnosing Endometrial Carcinoma. Contrast Media Mol Imaging. 2022 May:2022:7197505. doi: http://dx.doi.org/10.1155/2022/7197505 7. Thrastardottir TO, Copeland VJ, Constantinou C. The Association Between Nutrition, Obesity, Inflammation, and Endometrial Cancer: A Scoping Review. Curr Nutr Rep. 2023 Mar;12(1):98-121. doi: http://dx.doi.org/10.1007/s13668-022-00447-8 8. Xu H, Li J, Jin L, Zhang D, Chen B, Liu X, et al. Intrauterine hyperglycemia impairs endometrial receptivity via up-regulating SGK1 in diabetes. Sci China Life Sci. 2022 Aug;65(8):1578-89. doi: http://dx.doi.org/10.1007/s11427-021-2035-2 9. Kazachkova EA, Goshgarly AV, Voropaeva EE, Kazachkov EL, Rogozina AA. Comorbid gynecologic diseases and endometrial structure in women of different ages with uterine mucosal hyperplasia. Vestn Soveta Molodykh Uchenykh Spetsialistov Chelyab Obl. 2017;2(3):103-6. (In Russ.) 10. Popov AA, Alieva AS, Manannikova TN, Barto RA. Comparison of different ablation techniques for endometrial hyperplastic processes. RMZh Mat' Ditya. 2017;(26):1942-5. (In Russ.) 11. Kuai D, Tang Q, Tian W, Zhang H. Rapid identification of endometrial hyperplasia and endometrial endometrioid cancer in young women. Discov Oncol. 2023 Jul;14(1):121. doi: http://dx.doi.org/10.1007/s12672-023-00736-w 12. Lyzikova YuA, Smirnova MV. Determination of leptin and soluble leptin receptor levels in patients with endometrial hyperplastic processes. Problemy Zdorov'ya Ekologii. 2023;20(2):22-6. (In Russ.). doi: http://dx.doi.org/10.51523/2708-6011.2023-20-2-03 Information about authors: Yu.A. Lyzikova – Doctor of Medical Sciences, associate professor, professor of the Chair of Obstetrics and Gynecology with the course of the Faculty for Advanced Training & Retraining, Gomel State Medical University, https://orcid.org/0000-0002-8465-9368, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Yuliya. A. Lyzikova; M.V. Smirnova – ultrasound diagnostics doctor, Gomel City Clinical Hospital No. 2, https://orcid.org/0000-0002-2606-7006

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

References (10)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK