Association of M55L and Q192R polymorphisms of paraoxonase 1 gene (PON1) with recurrent pregnancy loss risk: A case-control study.

Alizadeh M, Nasiri M, Samadi M, Nasrin Ghasemi, Moradi A
International journal of reproductive biomedicine · 2021 · doi:10.18502/ijrm.v19i6.9377 · PMID:34401650 · PMC8350848
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This case-control study found that the RR genotype of the *PON1* Q192R polymorphism and the MM genotype of the *PON1* L55M polymorphism were significantly associated with recurrent pregnancy loss.

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This case-control study investigated the association between two paraoxonase 1 (PON1) gene polymorphisms, Q192R and L55M, and the risk of recurrent pregnancy loss in women. The researchers compared genotype frequencies in 110 women with a history of at least two miscarriages against 110 controls without such history, analyzing DNA from peripheral blood samples. The results indicated that the homozygous RR genotype for Q192R and the MM genotype for L55M were significantly associated with an increased risk of recurrent pregnancy loss. Relevance to endometriosis: The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

BackgroundRecurrent pregnancy loss (RPL) refers to the incidence of two or more abortions before the first half of pregnancy. Oxidative stress has been hypothesized to play a central role in RPL.ObjectiveTo investigate the relationship between Q192R and L55M polymorphisms of PON1 as antioxidant enzyme and the risk of RPL.Materials and methodsIn this case-control study, 110 women with RPL (case) and 110 healthy fertile women (control) referred to the Research and Clinical Center for Infertility, Shiraz, Iran were enrolled. Genomic DNA was extracted from the peripheral blood in all participants. Polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism method.ResultsStatistical analysis of Q192R polymorphism showed a significant difference for the RR genotype between the case and control group (OR = 11, CI = 1.39-86.87, p = 0.005) but none for the QR and QQ genotypes. No significant association was observed between the R and Q allelic frequency in the RPL participants compared to the control group (p = 0.53). Also, statistical analysis of the L55M polymorphism for MM genotype in the case group compared with the control group showed a significant difference (OR = 3.59, CI = 0.97-13.30, p = 0.042), but none for the LM and LL genotypes.ConclusionThe findings showed a significant correlation between the Q192R polymorphisms and the L55M PON1 enzyme and RPL in this study population.
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The findings of this study, which was conducted in Iran for the first time, showed that there is a clear correlation between the Q192R and L55M PON1 enzyme polymorphisms and RPL. In the near future, with the possibility of determining the genetic map and identifying the polymorphisms of each person, the frequency and susceptibility of each person to the diseases can be understood and treated for each person specifically. Hence the polymorphism studies help us for novel treatment concepts of RPL. In general, statistical studies should be repeated in different populations. Therefore, the present study cannot conclusively prove the relationship between Q192R and L55M polymorphism with RPL until it is repeated and confirmed by others. In the present study, PON1 polymorphisms were investigated, and it is recommended that the serum levels and activity be investigated in subsequent studies to be more conclusive.

Coi Statement

The authors declare no conflicts of interest.

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