malignant mimicker: Endometriosis presenting as a large solid–cystic pelvic mass with lymphadenopathy and distal ureteral invasion

In: The ASEAN Journal of Radiology · 2026 · vol. 27(2) , pp. 122–138 · doi:10.46475/asean-jr.v27i2.926 · W7162493762
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This case report describes endometriosis mimicking malignancy with a large pelvic mass, lymphadenopathy, and ureteral invasion, leading to suspicion of a malignant process.

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This paper reports a rare case of endometriosis with atypical symptoms and radiographic findings that mimicked malignancy. A patient presented with hematuria, and evaluation showed a large solid–cystic pelvic mass with skip lesions extending to the distal ureter, along with a focal lesion in the right external iliac region resembling nodal metastasis and evidence of distal ureteral invasion. The authors emphasize that endometriosis can be indistinguishable from cancer in certain imaging contexts, with an explicit limitation that this is a single case report. This paper is centrally about endometriosis — it describes endometriosis presenting as a malignant-appearing pelvic mass with lymphadenopathy and distal ureteral invasion.

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Abstract

Endometriosis presents with various imaging features. The most common site of endometriosis is the ovary, followed by the pelvic peritoneum. Less frequently affected sites include the deep subperitoneal tissues, the gastrointestinal tract, the urinary bladder, the thorax, and subcutaneous tissues. We present a rare case of endometriosis with atypical symptoms and radiographic features. The patient initially presented with hematuria. Evaluation revealed a pelvic mass with skip lesions extending to the distal ureter, mimicking malignancy. Focal endometriosis in the right external iliac region resembled nodal metastasis. These findings led clinicians and radiologists to suspect a malignant process. Consequently, endometriosis should be considered in the differential diagnosis under specific circumstances.
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A malignant mimicker: Endometriosis presenting as a large solid–cystic pelvic mass with lymphadenopathy and distal ureteral invasion DOI: https://doi.org/10.46475/asean-jr.v27i2.926Keywords: Endometriosis, Endometrioma, Carcinoma, Hematuria, Ureteritis, Ureteric invasionAbstract Endometriosis presents with various imaging features. The most common site of endometriosis is the ovary, followed by the pelvic peritoneum. Less frequently affected sites include the deep subperitoneal tissues, the gastrointestinal tract, the urinary bladder, the thorax, and subcutaneous tissues. We present a rare case of endometriosis with atypical symptoms and radiographic features. The patient initially presented with hematuria. Evaluation revealed a pelvic mass with skip lesions extending to the distal ureter, mimicking malignancy. Focal endometriosis in the right external iliac region resembled nodal metastasis. These findings led clinicians and radiologists to suspect a malignant process. Consequently, endometriosis should be considered in the differential diagnosis under specific circumstances. Downloads Metrics References Takeuchi M, Matsuzaki K, Harada M. Endometriosis, a common but enigmatic disease with many faces: current concept of pathophysiology, and diagnostic strategy. Jpn J Radiol 2024;42:801–19. doi: 10.1007/s11604-024-01569-5. DOI: https://doi.org/10.1007/s11604-024-01569-5 VanBuren W, Feldman M, Shenoy-Bhangle AS, Sakala MD, Young S, Chamie LP, et al. Radiology state-of-the-art review: Endometriosis imaging interpretation and reporting. Radiology 2024 ;312:e233482. doi: 10.1148/radiol.233482. DOI: https://doi.org/10.1148/radiol.233482 Leonardi M, Espada M, Kho RM, Magrina JF, Millischer AE, Savelli L, et al. Endometriosis and the urinary tract: From diagnosis to surgical treatment. Diagnostics (Basel) 2020 ;10:771. doi: 10.3390/diagnostics10100771. DOI: https://doi.org/10.3390/diagnostics10100771 Rennan L, Yao S, Jin H, Yi Q, Wang Y, Yang Y. Ureteral endometriosis: MR imaging appearance for predicting complex procedures. Heliyon 2024;10:e34884. doi: 10.1016/j.heliyon.2024.e34884. DOI: https://doi.org/10.1016/j.heliyon.2024.e34884 Chin S, Kitzing YX, Quesada J, Lo G. Endometriosis MRI : Atypical cases, pitfalls and mimics. J Med Imaging Radiat Oncol 2024;68:427–33. doi: 10.1111/1754-9485.13670. DOI: https://doi.org/10.1111/1754-9485.13670 Kido A, Himoto Y, Moribata Y, Kurata Y, Nakamoto Y. MRI in the diagnosis of endometriosis and related diseases. Korean J Radiol 2022;23:426-45. doi: 10.3348/kjr.2021.0405. DOI: https://doi.org/10.3348/kjr.2021.0405 Downloads Published How to Cite Issue Section License Copyright (c) 2026 The ASEAN Journal of Radiology This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Disclosure Forms and Copyright Agreements All authors listed on the manuscript must complete both the electronic copyright agreement. (in the case of acceptance)

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