Sublethal concentration of H2O2 enhances the protective effect of mesenchymal stem cells in rat model of spinal cord injury

Rahimi A, Asrin Rahimi, Iraj Amiri, Amiri I, Roushandeh AM, Amaneh Mohammadi Roushandeh, Zoleikha Golipour Choshali, Choshali ZG, Zohreh Alizadeh, Artimani T, Tayebeh Artimani, Saeid Afshar, Afshar S, Sara Soleimani Asl
Biotechnology letters · 2018 · vol. 40(3) , pp. 609–615 · doi:10.1007/s10529-017-2499-7 · PMID:29288352
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This study found that sublethal hydrogen peroxide exposure reduces mesenchymal stem cell migration but enhances brain-derived neurotrophic factor expression, suggesting improved protective effects against spinal cord injury.

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Abstract

OBJECTIVE: To investigate the effect of H2O2 on the migration and antioxidant defense of mesenchymal stem cells (MSCs) and the neurotrophic effects of H2O2-treated MSCs on spinal cord injury (SCI). RESULTS: Sublethal concentrations of H2O2 decreased cell migration and expression of CXCR4 and CCR2 as well as Nrf2 expression in MSCs. In the second phase, transplantation of treated and untreated MSCs to SCI caused minor changes in locomotor dysfunction. There was a significantly difference between cell-treated and spinal cord injury groups in expression of BDNF (brain-derived neurotrophic factor). Transplantation of H2O2-treated cells caused an increase in BDNF expression compared to non-treated cells. CONCLUSION: Transplantation of H2O2-treated stem cells may have protective effects against SCI through by increasing neurotrophic factors.

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MeSH descriptors

Hydrogen Peroxide Mesenchymal Stem Cells Mesenchymal Stem Cell Transplantation Spinal Cord Injuries Analysis of Variance Animals Brain-Derived Neurotrophic Factor Brain-Derived Neurotrophic Factor Cell Movement Cell Movement Female Hydrogen Peroxide Male Mesenchymal Stem Cells Mesenchymal Stem Cells NF-E2-Related Factor 2 NF-E2-Related Factor 2 Rats Rats, Wistar Spinal Cord Injuries

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