Characteristic of immunophenotypes of normal endometrial, eutopic and ectopic endometrial tissue in women with endometriosis and infertility.

M.V. Medvedev, Mykhailo Medvediev, I. S. Spon'ka, О.М. Алтанець, V. R. Skoryk
In: Morphologia · 2018 · vol. 12(2) , pp. 46–54 · doi:10.26641/1997-9665.2018.2.46-54 · W2886787436
article OA: diamond CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study assessed immunohistochemical markers in normal, eutopic, and ectopic endometrial tissues from women with endometriosis and infertility, finding differences between normal and other tissues but not between eutopic and ectopic endometria.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study assessed immunohistochemical expression of ER, PGR, Ki-67, BCL-2, and MMP-9 in normal endometrium, eutopic endometrium, and ectopic endometrial tissue from women with endometriosis and infertility, using expression patterns in glands and stroma to form groups and staining assessed across at least 10 fields of view. The authors found statistical differences between normal endometrium and both eutopic and ectopic endometrium for ER, PGR, and MMP-9, and between normal and eutopic endometrium for BCL-2 and Ki-67, while there were no statistical differences between eutopic and ectopic tissues. The paper’s main caveat is that it does not report a specific limitation in the provided text beyond relying on immunohistochemical marker differences and group formation criteria. This paper is centrally about endometriosis — it characterizes immunophenotypic marker profiles across normal, eutopic, and ectopic endometrial tissues in women with endometriosis-related infertility.

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Abstract

Background. Endometriosis is considered as one of the most common causes of infertility in women. Despite the numerous published data on this subject, early stage diagnosis remains very low. Histologically normal endometriosis does not differ from the eutopic endometrium, so the search for features is transferred to the molecular level. Objective. Assess immunohistochemical markers ER, PGR, Ki-67, BCL-2, MMP-9 in normal endometrial, eutopic and ectopic endometrial tissue in women with endometriosis and infertility. Methods. 3 groups were divided according to expression of investigated marker in glands (ER, PGR, Ki-67, BCL-2, MMP-9) and stroma (ER, PGR, Ki-67). The strict included/excluded options (clinical and/or morphological) were used for organizing these groups. Rating staining immunohistochemical markers was conducted in at least 10 fields of view. Statistical processing of the data included nonparametric tests. Results. The statistical difference between normal endometrium and both eutopic and ectopic endometrium was established for markers ER, PGR, MMP-9; between normal and eutopic endometrium was set for markers BCL-2, Ki-67 (p <0.05 on all of characteristics). No case was there with statistical difference between eutopic and ectopic endometrium. Conclusion. For the diagnosis of endometriosis with women with infertility the complex of immunohistochemical markers ER, PGR, MMP-9 can be useful and also BCL-2, Ki-67 could be added as ability for improving an accuracy of suggested method.

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endometriosisinfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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