Editorial: Fertility-preserving and fertility-sparing treatment approaches in gynecologic malignancies.

Raimondo D, Raffone A, Daniele Neola, Giuseppe Vizzielli, Caserta D, Hall M, Paolo Casadio, Seracchioli R, Driul L, Restaino S
Frontiers in oncology · 2023 · doi:10.3389/fonc.2023.1199582 · PMID:37333826 · PMC10272815
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This editorial outlines a research topic on fertility-sparing treatments for gynecologic malignancies, particularly endometrial carcinoma, highlighting studies on conservative management criteria, obesity impacts, maintenance therapies, and traditional Chinese medicine applications.

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This editorial reviews a research topic focused on fertility-sparing strategies for gynecologic malignancies, particularly endometrial carcinoma and ovarian cancer in women of childbearing age. It highlights various studies addressing treatment protocols, the impact of obesity and metabolic syndrome on outcomes, and methods to prevent recurrence while preserving reproductive potential. The text also notes that some included therapies, such as Guizhi Fuling Wan, are traditionally used for benign conditions but are being evaluated for their efficacy in malignant contexts. Relevance to endometriosis: mentioned tangentially only because one reviewed study investigates a traditional Chinese medicine (Guizhi Fuling Wan) that is commonly used to treat endometriosis, although the paper's primary focus remains on oncological fertility preservation.

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References

1 SinghNHirschowitzLZainoRAlvarado-CabreroIDugganMAAli-FehmiRet al. Pathologic prognostic factors in endometrial carcinoma (Other than tumor type and grade). Int J Gynecol Pathol (2019) 38(1):S93–113. doi: 10.1097/PGP.0000000000000524 2 FinerLBPhilbinJM. Trends in ages at key reproductive transitions in the united states, 1951-2010. Womens Health Issues (2014) 24(3):e271–9. doi: 10.1016/J.WHI.2014.02.002 3 De FeliceFMarchettiCDi PintoAMusellaAPalaiaIPorporaMGet al. Fertility preservation in gynaecologic cancers. Ecancermedicalscience (2018) 12:798. doi: 10.3332/ECANCER.2018.798 4 Howard-AndersonJGanzPABowerJEStantonAL. Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: a systematic review. J Natl Cancer Inst (2012) 104(5):386–405. doi: 10.1093/JNCI/DJR541 5 CanadaALSchoverLR. The psychosocial impact of interrupted childbearing in long-term female cancer survivors. Psychooncology (2012) 21(2):134–43. doi: 10.1002/PON.1875 6 Diaz-GarciaCDomingoJGarcia-VelascoJAHerraizSMirabetVIniestaIet al. Oocyte vitrification versus ovarian cortex transplantation in fertility preservation for adult women undergoing gonadotoxic treatments: a prospective cohort study. Fertil Steril (2018) 109(3):478–485.e2. doi: 10.1016/J.FERTNSTERT.2017.11.018 7 KvarnströmNJärvholmSJohannessonLDahm-KählerPOlaussonMBrännströmM. Live donors of the initial observational study of uterus transplantation-psychological and medical follow-up until 1 year after surgery in the 9 cases. Transplantation (2017) 101(3):664–70. doi: 10.1097/TP.0000000000001567 8 CasadioPLa RosaMAllettoAMagnarelliGArenaAFontanaEet al. Fertility sparing treatment of endometrial cancer with and without initial infiltration of myometrium: a single center experience. Cancers (Basel) (2020) 12(12):1–9. doi: 10.3390/CANCERS12123571 9 Gueli AllettiSRestainoSFinelliARonsiniCLucidiAScambiaGet al. Step by step total laparoscopic hysterectomy with uterine arteries ligation at the origin. J Minim Invasive Gynecol (2020) 27(1):22–3. doi: 10.1016/j.jmig.2019.06.001 10 RodolakisAScambiaGPlanchampFAcienMDi Spiezio SardoAFarrugiaMet al. ESGO/ESHRE/ESGE guidelines for the fertility-sparing treatment of patients with endometrial carcinoma. Int J Gynecol Cancer (2023) 33(2):208–22. doi: 10.1136/IJGC-2022-004047 11 AubreyCBlackKCampbellSPinS. Endometrial cancer and bariatric surgery: a scoping review. Surg Obes Relat Dis (2019) 15(3):497–501. doi: 10.1016/J.SOARD.2018.12.003 12 SantosMLPaisASAlmeida SantosT. Fertility preservation in ovarian cancer patients. Gynecol Endocrinol (2021) 37(6):483–9. doi: 10.1080/09513590.2021.1872534 Summary

Keywords

cancer, tumor, oncofertility, reproduction, offspring Citation Raimondo D, Raffone A, Neola D, Vizzielli G, Caserta D, Hall M, Casadio P, Seracchioli R, Driul L and Restaino S (2023) Editorial: Fertility-preserving and fertility-sparing treatment approaches in gynecologic malignancies. Front. Oncol. 13:1199582. doi: 10.3389/fonc.2023.1199582 Received 03 April 2023 Accepted 23 May 2023 Published 02 June 2023 Volume 13 - 2023 Edited and reviewed by Sophia George, University of Miami, United States Updates Copyright © 2023 Raimondo, Raffone, Neola, Vizzielli, Caserta, Hall, Casadio, Seracchioli, Driul and Restaino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. *Correspondence: Antonio Raffone, [email protected]; Giuseppe Vizzielli, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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