The effect of a gonadotrophin-releasing hormone analogue as first-line management in cyclical pelvic pain

Niki Baxter, Baxter N, Jean Black, Black J, Duffy S, S. Duffy, Sean Duffy
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2003 · vol. 24(1) , pp. 64–66 · doi:10.1080/01443610310001620323 · PMID:14675984 · W2117265631
Non-randomised trial OA: closed CC0 ⤵ 5 in-corpus citations
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This pilot study found that leuprorelin acetate significantly reduced pelvic pain scores and improved symptoms in women with cyclical pelvic pain, regardless of endometriosis severity.

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Abstract

One of the most common gynaecological causes of chronic pelvic pain is endometriosis. A lack of correlation between laparoscopic findings and pelvic pain has been reported. As endometriotic lesions are under hormonal influence, the effects of the gonadotrophin-releasing hormone (GnRH) analogues cause shrinkage of the deposits, reducing symptoms caused by them. We carried out a longitudinal, interventional pilot study, examining the effect of leuprorelin acetate 3.75 mg (Prostap SR, Wyeth) on pelvic pain prospectively. Preliminary data shows a decrease in pain scores from before to after treatment which is statistically significant (P<0.0001) as well as a general improvement in other symptoms. Laparoscopy showed that symptom intensity is not always related to severity of endometriosis and the worst symptoms may not necessarily be due to pathology. Therefore, it is beneficial to treat women with CPP with GnRH analogues as first-line management to relieve painful symptoms, avoid surgical risks and save money.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Leuprolide Pelvic Pain Periodicity Periodicity Adult Adult Chronic Disease Chronic Disease Dose-Response Relationship, Drug Dose-Response Relationship, Drug Drug Administration Schedule Drug Administration Schedule Endometriosis Endometriosis Endometriosis Endometriosis Female Female Follow-Up Studies

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (5)

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