Endometrial stem/progenitor cells and proliferative disorders of the endometrium
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⤵ 20 in-corpus citations
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This review presents evidence for the existence of epithelial and stromal stem/progenitor cells in the endometrium, which may offer insights into gynecological disorders and tissue engineering applications.
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Abstract
The human endometrium undergoes cyclical processes of regeneration, differentiation and shedding as part of the menstrual cycle. In non-menstruating species, there are cycles of endometrial growth and apoptosis rather than physical shedding. It was hypothesized many years ago that endometrial stem cells are responsible for the remarkable regenerative capacity of endometrium. In this review, we summarize the first data providing evidence for the presence of adult stem/progenitor cells in human and mouse endometrium using functional assays. This is because adult stem cells are defined by their functional properties rather than by marker expression, and there are no known markers of endometrial stem/progenitor cells. Evidence will be presented which demonstrates that the endometrium contains rare populations of both and epithelial and stromal stem/progenitor cells. These fundamental studies on endometrial stem/progenitor cells will provide new insights into the pathophysiology of various gynecological disorders associated with abnormal endometrial proliferation, including endometriosis, endometrial cancer, endometrial hyperplasia, and adenomyosis. The possible use of endometrial stem/progenitor cells in tissue engineering applications relevant to urogynecology will also be mentioned.
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Cited by (20)
- Análise exploratória do miRNoma de células-tronco mesenquimais isoladas de fluxo menstrual de mulheres com endometriose 2023
- Faculty Opinions recommendation of The elusive endometrial epithelial stem/progenitor cells. 2021
- The Role of miRNAs 340-5p, 92a-3p, and 381-3p in Patients with Endometriosis: A Plasma and Mesenchymal Stem-Like Cell Study 2021
- Progesterone Resistance and Adult Stem Cells’ Genomic and Epigenetic Changes in the Puzzle of Endometriosis 2019
- Inflammatory cytokine profile of co‑cultivated primary cells from the endometrium of women with and without endometriosis 2018
- Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients 2016
- Lentiviral vector-mediated down-regulation of Notch1 in endometrial stem cells results in proliferation and migration in endometriosis 2016
- Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis 2015
- Somatic stem cells and their dysfunction in endometriosis 2015
- Endometriosis: Are Stem Cells Involved? 2015
- Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis 2014
- Krüppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis 2014
- Aberrant telomerase expression in the endometrium of infertile women with deep endometriosis 2013
- Endometriosis: the role of neuroangiogenesis 2011
- Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis 2011
- The emerging role of epigenetics in the aetiology of endometriosis. 2011
- The Endometrium: A Novel Source of Adult Stem/Progenitor Cells 2009
- Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma 2008
- Hormone and growth factor signaling in endometrial renewal: role of stem/progenitor cells 2008
- Estrogen is not essential for full endometrial restoration after breakdown: lessons from a mouse model 2007
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- europepmc
- last seen: 2026-10-25T09:32:14.900964+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:04:05.892929+00:00
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