Alpha-methyltyptamine blocks facilitation of lordosis by progesterone in spayed, extrogen-primed rats

C Espino, Conchita Espino, Mary Sano, M Sano, George N. Wade, G N Wade
Pharmacology, biochemistry, and behavior · 1975 · vol. 3(4) , pp. 557–559 · doi:10.1016/0091-3057(75)90172-0 · PMID:1187719 · W2083472333
Lab / animal OA: closed CC0 ⤵ 3 in-corpus citations
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Alpha-methyltryptamine inhibited progesterone-induced sexual receptivity in estrogen-primed rats, supporting the hypothesis that progesterone facilitates lordosis by inhibiting a serotonergic system.

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Abstract

Alpha-methyltryptamine, a drug which stimulates serotonergic receptors in the central nervous system, inhibited the induction of sexual receptivity in spayed female rats by estradiol benzoate and progesterone. The drug had no effect on the sexual receptivity induced by estradiol benzoate alone. These data are consistent with the hypothesis that progesterone facilitates lordosis in estrogen-primed rats by inhibiting a serotonergic system in the brain. The data also suggest that estradiol and progesterone act on separate neurochemical systems to induce estrous behavior in rats.

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MeSH descriptors

Estradiol Posture Progesterone Sexual Behavior, Animal Tryptamines Animals Castration Estradiol Female Male Ovary Ovary Progesterone Progesterone Rats Receptors, Drug Receptors, Drug Serotonin Serotonin Sexual Behavior, Animal

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