Suppression of lordosis behavior by the putative 5-HT receptor agonist 8-OH-DPAT in the rat

Sven Ahlénius, Alonso Fernández‐Guasti, Stephan Hjorth, Knut Larsson
In: European Journal of Pharmacology · 1986 · vol. 124(3) , pp. 361–363 · doi:10.1016/0014-2999(86)90241-4 · PMID:2942412 · W2029510597
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8-OH-DPAT administration inhibited lordosis behavior in ovariectomized rats, supporting a role for central 5-HT in inhibiting this behavior.

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Abstract

The administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), inhibited the lordosis induced by estradiol benzoate or estradiol benzoate plus progesterone in ovariectomized rats. There was no facilitation of lordosis by 8-OH-DPAT in animals pretreated with a threshold dose of estradiol benzoate. The results are consistent with the view that 8-OH-DPAT is an agonist at 5-HT receptors and provide further support for an inhibition role of central 5-HT in the mediation of lordosis behavior.

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