The Effect of Ambulation on Vaginal Distribution of Miconazole Nitrate (1200 mg)

Seema Menon, Adrianna Izquierdo, Mark Rosen, Amy Hummel, Kurt T. Barnhart
In: Journal of Women's Health · 2007 · vol. 16(5) , pp. 703–706 · doi:10.1089/jwh.2006.0163 · PMID:17627405 · W2079326289
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher

Abstract

OBJECTIVE: To evaluate the effect activity has on the vaginal distribution of a 1200 mg miconazole nitrate gelatin encapsulated insert, an antifungal agent commonly used to treat vaginal vulvocandidiasis. METHOD: Nine subjects underwent two sessions of serial magnetic resonance imaging after insertion of the insert. One session required that the subjects ambulate between images; the other session required the subjects remain supine between images. Vaginal distribution of the insert was quantified by calculating surface contact and linear distance in every image. Comparison of spread was then done between images taken in active subjects and images taken in resting subjects. Time until capsule dissolution was also compared between the two groups. RESULTS: No statistically significant difference was seen in spread of insert between the active and resting group. Activity also had no significant effect on capsule dissolution. CONCLUSION: Activity does not appear to hinder the spread of the insert, suggesting that this medication can be used daytime or nighttime.

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (13)

Source provenance

openalex
last seen: 2026-05-11T05:18:01.733872+00:00
unpaywall
last seen: 2026-08-22T06:23:50.750314+00:00
License: CC0 · commercial use OK