Aetiology and pathogenesis of endometriosis - a review
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⤵ 10 in-corpus citations
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Endometriosis develops from ectopic endometrial cell implantation, likely influenced by genetic predisposition, environmental factors causing immunosuppression, and hormonal dysregulation.
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Abstract
Endometriosis is a complex gynaecological disorder that affects nearly 1 in 7 women of reproductive age. Ectopic dissemination of endometrial cell and their subsequent implantation are the mechanisms involved in the development of endometriosis. Endometriosis is a common multifactorial disease caused by an interaction between multiple gene loci and environment. Causes of stress on immune functioning or may be genetically determined. Environmental factors can be responsible for immunosuppressive activities in patient with endometriosis. In addition, toxin modulates steroid receptors expression resulting in altered tissue specific responses to hormones. Chronic immunosuppression in combination with hormonal regulation may have facilitated the aberrant growth of endometrial tissue within the peritoneum. However, the mechanism appears to require endometrium and retrograde menstruation in most cases of the disease.
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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
Cited by (10)
- Clinical case of differential diagnosis of retrocervical endometriosis 2021
- Vitamin D deficiency as a risk factor for endometriosis in Iranian women 2020
- Efficacy of ten interventions for endometriosis: A network meta-analysis 2019
- DIAGNOSTIC SIGNIFICANCE OF IMMUNOHISTOCHEMICAL ENDOMETRIAL STUDIES IN INFERTILITY IN WOMEN WITH MILD ENDOMETRIOSIS 2018
- Endometriosi e infertilità: impatto su sessualità, relazione di coppia, qualità della vita e benessere psicologico 2017
- Prevalence of high-risk human papillomavirus infection in women with ovarian endometriosis 2016
- The use of combined oral contraceptives in the prevention and treatment of endometriosis 2015
- Quality of life and sexual satisfaction in women suffering from endometriosis: An Italian preliminary study 2015
- A comparison of progestogens or oral contraceptives and gonadotropin-releasing hormone agonists for the treatment of endometriosis: a systematic review 2014
- Место комбинированных оральных контрацептивов в лечении эндометриоза 2013
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- europepmc
- last seen: 2026-10-13T06:10:10.580696+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:11:31.379484+00:00
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