Increased risk of depression before and after unilateral or bilateral oophorectomy: A self-controlled case series study using a nationwide cohort in South Korea

Hyewon Kim, Yuwon Kim, Maurizio Fava, David Mischoulon, Myung-Hee Shin, Myung‐Hee Shin, Dong-Yun Lee, Dong‐Yun Lee, Hong Jin Jeon
Journal of affective disorders · 2021 · vol. 285 , pp. 47–54 · doi:10.1016/j.jad.2021.02.003 · PMID:33631480 · W3127090413
Observational OA: closed CC0 ⤵ 1 in-corpus citation
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This study found that individuals who underwent unilateral or bilateral oophorectomy experienced an increased risk of depression both before and after the surgery.

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Abstract

BACKGROUND: There is insufficient evidence of the association between oophorectomy and depression. METHODS: A nationwide medical records database of South Korea was used to investigate incidence rate ratios (IRRs) of major depressive disorder before and after oophorectomy (n = 36,284) using a self-controlled case series design. Outcomes before and after hysterectomy (n = 25,415) were identified to compare with those around oophorectomy. RESULTS: In all oophorectomy and hysterectomy groups, the risk of depression was increased before and after surgery, peaking immediately before or after the operation, with no significant difference in the pattern of the results according to type of surgery. In the bilateral oophorectomy group, the IRR was increased between 2-3 months before the surgery, peaking immediately before surgery at 1.39 (95% CI: 1.30-1.49, p < .0001), and remained heightened for one-year postexposure. Subgroup analyses performed according to ovarian cancer, age group, and hormone replacement therapy produced results similar to those of the main outcome. LIMITATIONS: Because we used claims data, the detailed clinical information related to oophorectomy is lacking. There is possibility that time-varying confounder besides age and season might have affected the results CONCLUSIONS: The risk of depression increased before and after oophorectomy. The increase in risk of depression started before oophorectomy and peaked immediately before or after the operation, but no significant differences between unilateral and bilateral surgery and cancer and noncancer or among age groups were noted.

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MeSH descriptors

Depression Major Depressive Disorder Major Depressive Disorder Cohort Studies Female Humans Ovariectomy Republic of Korea Republic of Korea

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