A INFLUÊNCIA DA ALIMENTAÇÃO NA PREVENÇÃO, TRATAMENTO E SINTOMATOLOGIA EM MULHERES COM ENDOMETRIOSE: UMA REVISÃO SISTEMÁTICA

Beatriz Cássia de Queiroz, Julia Jack Macedo, Flávia Teixeira Kéller, Vanessa Menezes Ferreira Bachini
In: REMUNOM · 2025 · vol. 20(2) , pp. 1–17 · doi:10.66104/p2awjm36 · W7152674827
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This systematic review found that calcium from dairy, carotenoids, anti-inflammatory diets, and supplements like omega-3 may help prevent and treat endometriosis symptoms.

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This systematic review evaluated studies published from 2020 to 2025 on how diet influences the prevention, treatment, and symptomatology of endometriosis, searching Scielo, Google Scholar, PubMed, and Lilacs and including 8 articles that met inclusion criteria. It found evidence spanning lower endometriosis risk associated with adequate calcium-rich dairy intake during adolescence (2 articles), a relationship between serum carotenoid levels and endometriosis risk (1 article), dietary modifications such as excluding gluten, milk, and soy and adopting vegetables or Low FODMAP and “endometriosis” diets to reduce pain and improve symptoms (2 articles), and anti-inflammatory supplements including omega-3 and vitamins C and E with positive effects on inflammation/oxidative stress (3 articles). The review’s main limitation is that only a small number of heterogeneous studies (8 total) were included, and the mechanism and efficacy of specific nutritional components like carotenoids require further confirmation. This paper is centrally about endometriosis—analyzing how dietary patterns, specific nutrients (calcium, carotenoids), and anti-inflammatory dietary interventions relate to prevention and symptom outcomes in women with the condition.

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Abstract

A endometriose é uma enfermidade inflamatória crônica, sensível às variações hormonais, que acomete mulheres durante a fase reprodutiva, caracterizada pela presença de tecido semelhante ao endométrio localizado fora do útero, acometendo cerca de 10% das mulheres em idade fértil sendo uma das principais responsáveis por dores pélvicas persistentes, dispareunia, dismenorreia e problemas relacionados à fertilidade, sua origem é multifatorial, englobando aspectos genéticos, imunológicos, hormonais e ambientais. Material e métodos: Foi conduzido um levantamento de estudos nas bases de dados da Scielo, Google Acadêmico, Pubmed, Lilacs, publicados entre os anos de 2020 a 2025, capturando 8 artigos que preencheram todos os critérios de inclusão. Resultados: Dos 8 estudos analisados, 2 artigos avaliaram que o consumo de cálcio proveniente de laticínios na adolescência na prevenção de surgimento da endometriose. 1 artigo avaliou a relação entre níveis séricos de carotenoides e o risco de endometriose. 2 artigos avaliaram modificações alimentares como retirada de glúten, leite e soja e a inclusão de vegetais e dieta com Low FODMAP e dieta para endometriose auxiliam na redução da dor e sintomas da endometriose. 3 artigos avaliaram a utilização e suplementos com efeito anti-inflamatório. Conclusões: O resultado da presente pesquisa, demonstrou que o consumo adequado de laticínios fontes de cálcio, está associado a menor risco de desenvolvimento da endometriose, principalmente quando introduzido desde a adolescência. A alimentação rica em carotenoides pode ser uma estratégia preventiva, embora sejam necessários mais estudos que comprovem seu mecanismo de ação e eficácia. As intervenções dietéticas como dietas anti-inflamatórias, Low FODMAP ou com exclusão de glúten, laticínios e soja, podem reduzir a dor pélvica, além de contribuir na melhora dos sintomas e na qualidade de vida. A suplementação com ômega-3 e vitaminas C e E, também mostrou resultados positivos na diminuição da inflamação e do estresse oxidativo, indicando benefícios no tratamento complementar.
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THE INFLUENCE OF DIET ON THE PREVENTION, TREATMENT, AND SYMPTOMATOLOGY IN WOMEN WITH ENDOMETRIOSIS: A SYSTEMATIC REVIEW. DOI: https://doi.org/10.66104/p2awjm36Keywords: Nutrition; women's health; food consumption; chronic inflammation.Abstract Endometriosis is a chronic inflammatory disease, sensitive to hormonal variations, that affects women during their reproductive years. It is characterized by the presence of tissue similar to the endometrium located outside the uterus, affecting approximately 10% of women of childbearing age. It is one of the main causes of persistent pelvic pain, dyspareunia, dysmenorrhea, and fertility-related problems. Its origin is multifactorial, encompassing genetic, immunological, hormonal, and environmental aspects. Materials and methods: A survey of studies published between 2020 and 2025 was conducted in the Scielo, Google Scholar, Pubmed, and Lilacs databases, capturing 8 articles that met all inclusion criteria. Results: Of the 8 studies analyzed, 2 articles evaluated the role of calcium consumption from dairy products during adolescence in preventing the onset of endometriosis. 1 article evaluated the relationship between serum carotenoid levels and the risk of endometriosis. 2 articles evaluated dietary modifications such as the removal of gluten, milk, and soy, and the inclusion of vegetables and a Low FODMAP diet, as well as a diet for endometriosis, in reducing pain and symptoms of endometriosis. 3 articles evaluated the use of supplements with anti-inflammatory effects. Conclusions: The results of this research demonstrated that adequate consumption of dairy products rich in calcium is associated with a lower risk of developing endometriosis, especially when introduced during adolescence. A diet rich in carotenoids may be a preventive strategy, although further studies are needed to confirm its mechanism of action and efficacy. Dietary interventions such as anti-inflammatory diets, low-FODMAP diets, or diets excluding gluten, dairy, and soy can reduce pelvic pain, as well as contribute to the improvement of symptoms and quality of life. Supplementation with omega-3 and vitamins C and E also showed positive results in reducing inflammation and oxidative stress, indicating benefits in complementary treatment. Downloads References ABOKHRAIS, I. M. et al. Erratum: A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1). PLoS ONE, v. 15, n. 2, p. 1–13, 2020. DOI: 10.1371/journal.pone.0227695. Disponível em: https://doi.org/10.1371/journal.pone.0227695. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1371/journal.pone.0230055 AMINI, L. et al. The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial. Pain Research and Management, v. 2021, p. 1–9, 2021. DOI: 10.1155/2021/5529741. Disponível em: https://doi.org/10.1155/2021/5529741. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1155/2021/5529741 ASHRAFI, M. M. D. et al. Diet and the risk of endometriosis in Iranian women: a case-control study. International Journal of Fertility and Sterility, v. 14, n. 3, p. 193–200, 2020. Disponível em: https://ijfs.ir/article_45721.html. Acesso em: 7 nov. 2025. CALDER, P. C. Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, v. 1851, n. 4, p. 469–484, 2015. DOI: 10.1016/j.bbalip.2014.08.010. Disponível em: https://doi.org/10.1016/j.bbalip.2014.08.010. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1016/j.bbalip.2014.08.010 COONEY, M. A. et al. Organochlorine pesticides and endometriosis. Reproductive Toxicology, v. 30, n. 3, p. 365–369, 2010. Disponível em: https://www.sciencedirect.com/journal/reproductive-toxicology. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1016/j.reprotox.2010.05.011 HARRIS, H. R. et al. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. American Journal of Epidemiology, v. 177, p. 420–430, 2013. Disponível em: https://academic.oup.com/aje. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1093/aje/kws247 HORNE, A. W.; MISSMER, S. A. Pathophysiology, diagnosis, and management of endometriosis. BMJ, v. 379, e070750, 2022. DOI: 10.1136/bmj-2022-070750. Disponível em: https://doi.org/10.1136/bmj-2022-070750. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1136/bmj-2022-070750 HUIJS, E.; NAP, A. The effects of nutrients on symptoms in women with endometriosis: a systematic review. Reproductive Biomedicine Online, v. 41, n. 2, p. 317–328, 2020. Disponível em: https://www.rbmojournal.com. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1016/j.rbmo.2020.04.014 HUANG, J. Association between serum carotenoids levels and endometriosis risk: evidence from the National Health and Nutrition Examination Survey. Frontiers in Nutrition, v. 12, 1513191, 2025. DOI: 10.3389/fnut.2025.1513191. Disponível em: https://doi.org/10.3389/fnut.2025.1513191. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.3389/fnut.2025.1513191 KRABBENBORG, I.; ROOS, N.; GRINTEN, P. V.; NAP, A. Diet quality and perceived effects of dietary changes in Dutch endometriosis patients: an observational study. Reproductive BioMedicine, v. 43, n. 5, p. 952–961, 2021. Disponível em: https://www.rbmojournal.com. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1016/j.rbmo.2021.07.011 LEE, H. J. et al. Dietary pattern and risk of endometrioma in Korean women: a case-control study. Obstetrics & Gynecology Science, v. 64, n. 1, p. 99–106, 2021. Disponível em: https://www.rbmojournal.com. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.5468/ogs.20230 LOOMAN, M. et al. Development and evaluation of the Dutch Healthy Diet index 2015. Public Health Nutrition, v. 20, n. 13, p. 2289–2299, 2017. Disponível em: https://doi.org/10.1017/S136898001700091X. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1017/S136898001700091X NODLER, M. D. Dairy consumption during adolescence and endometriosis risk. American Journal of Obstetrics and Gynecology, v. 222, n. 3, p. 251–257, 2020. Disponível em: https://www.ajog.org. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1016/j.ajog.2019.09.010 RAFIQUE, S.; DECHERNEY, A. H. Medical management of endometriosis. Clinical Obstetrics and Gynecology, v. 60, n. 3, p. 485–496, 2017. Disponível em: https://www.ajog.org. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1097/GRF.0000000000000292 SAINI, R. K. et al. Carotenoids: dietary sources, extraction, encapsulation, bioavailability, and health benefits – a review of recent advancements. Antioxidants (Basel), v. 11, n. 4, p. 795, 2022. DOI: 10.3390/antiox11040795. Disponível em: https://doi.org/10.3390/antiox11040795. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.3390/antiox11040795 TRABERT, B. et al. Diet and risk of endometriosis in a population-based case-control study. British Journal of Nutrition, v. 105, p. 459–467, 2011. Disponível em: https://doi.org/10.1017/S0007114510003661. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1017/S0007114510003661 UPSON, K. et al. Organochlorine pesticides and risk of endometriosis: findings from a population-based case–control study. Environmental Health Perspectives, v. 121, n. 11–12, p. 1319–1324, 2013. Disponível em: https://doi.org/10.1289/ehp.1306648. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1289/ehp.1306648 VAN HAAPS, A. P. et al. The effect of dietary interventions on pain and quality of life in women diagnosed with endometriosis: a prospective study with control group. Human Reproduction (Oxford, England), v. 38, n. 12, p. 2433–2446, 2023. DOI: 10.1093/humrep/dead214. Disponível em: https://doi.org/10.1093/humrep/dead214. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1093/humrep/dead214 VERCELLINI, P. et al. Endometriosis: pathogenesis and treatment. Nature Reviews Endocrinology, v. 10, n. 5, p. 261–275, 2014. Disponível em: https://doi.org/10.1038/nrendo.2013.255. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1038/nrendo.2013.255 ZONDERVAN, K. T.; BECKER, C. M.; MISSMER, S. A. Endometriosis. New England Journal of Medicine, v. 13, p. 1244–1256, 2020. Disponível em: https://www.nejm.org. Acesso em: 7 nov. 2025. DOI: https://doi.org/10.1056/NEJMra1810764 Downloads Published Issue Section License Copyright (c) 2025 Beatriz Cássia de Queiroz , Julia Jack Macedo , Flávia Teixeira Keller , Vanessa Menezes Ferreira Bachini This work is licensed under a Creative Commons Attribution 4.0 International License. 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