Color flow pulsed Doppler ultrasound in diagnosing luteal phase defect

Jacob L. Glock, J L Glock, John R. Brumsted, J R Brumsted
Fertility and sterility · 1995 · vol. 64(3) , pp. 500–504 · doi:10.1016/s0015-0282(16)57783-8 · PMID:7641901 · W16136752
Other OA: closed CC0 ⤵ 5 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-29 ⓘ

This prospective study found that women with luteal phase defect exhibited significantly higher corpus luteum blood flow resistance indices than normal women, suggesting color flow pulsed Doppler analysis may aid in assessing luteal phase adequacy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To determine whether color flow pulsed Doppler analysis of corpus luteum blood flow in normal cycles differs from cycles with a luteal phase defect. DESIGN: A prospective study of natural ovarian cycles. SETTING: The University of Vermont Reproductive Endocrinology and Infertility Service. PATIENTS: Ten women with regular menstrual cycles and at risk for luteal phase defect (LPD) four with unexplained infertility, two with recurrent abortion, and four with age > 35 years. INTERVENTIONS: All women were examined by transvaginal color flow pulsed Doppler during the early follicular, late follicular, early luteal, midluteal, and late luteal phase of the menstrual cycle. Venous blood for P concentration was drawn on each day of Doppler exam. Urine testing for LH surge and endometrial biopsy during the late luteal phase were performed on each patient. MAIN OUTCOME MEASURES: Lowest resistance index associated with the highest amplitude signal from intraovarian vessels of each ovary, dated endometrial biopsies, serum P. RESULTS: Mean resistance indexes in LPD patients (n = 3) were significantly higher compared with normal women (n = 6) throughout the follicular and luteal phases. One patient remained anovulatory and was excluded from statistical analysis. Although systolic and diastolic velocities generally were observed to be lower in LPD patients compared with normal women, these differences were not statistically significant. High correlations were observed between P and resistance index within each luteal time point, achieving its highest value during the midluteal phase. CONCLUSIONS: This initial study provides evidence that color flow pulsed Doppler analysis of blood flow impedance to the corpus luteum may aid in assessing luteal phase adequacy.

My notes (saved in your browser only)

MeSH descriptors

Corpus Luteum Infertility, Female Luteal Phase Abortion, Habitual Abortion, Habitual Adult Biopsy Corpus Luteum Endometrium Endometrium Female Humans Infertility, Female Infertility, Female Luteinizing Hormone Luteinizing Hormone Pregnancy Progesterone Progesterone Prospective Studies

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (12)

Cited by (5)

Source provenance

openalex
last seen: 2026-05-14T06:18:11.163272+00:00
pubmed
last seen: 2026-10-08T21:58:54.395363+00:00
unpaywall
last seen: 2026-09-17T06:32:46.214484+00:00
License: CC0 · commercial use OK