Pharmacokinetic and pharmacodynamic studies of vaginal rings releasing low-dose levonorgestrel
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This study investigated a low-dose levonorgestrel vaginal ring in 15 women, finding that ovulation occurred in 36% of treatment cycles with varying luteal function and anovulatory reactions, alongside distinct individual differences in drug levels and bleeding patterns.
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Abstract
Pharmacokinetic and pharmacodynamic effects of a vaginal ring releasing 20 micrograms/day levonorgestrel (L-NOG) have been studied in 15 women. Serum levels of L-NOG, estradiol and progesterone were measured three times a week in a control menstrual cycle and a treatment period of 3 months after the insertion of the first vaginal ring. All control cycles were normal ovulatory. Among the 36 treatment cycles 13 were ovulatory (36%), 5 ovulatory with inadequate luteal function (14%), 14 anovulatory but with marked follicle activity (39%) and 4 anovulatory (11%). In the groups with ovulatory reaction the serum levels of L-NOG showed a decline of 54% of the initial level at the end of the treatment period, calculated according to the linear regression equation of Y = 0.903-0.0142X, while in the groups without ovulation the L-NOG levels were higher and the decline was 24% of the initial level (Y = 1.034-0.0086X). There were distinct individual differences in the levels of L-NOG and ovarian reactions. Marked follicle activity with very high estradiol levels were found in correlation with high L-NOG in 7 treatment cycles, particularly in the B type of reaction (B = anovulatory cycle with marked follicle activity). More intermenstrual bleeding and spotting occurred in the second treatment cycles, particularly in those with anovulatory reactions.
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Too few in-corpus citations on either side for a chart; here are the lists.
Cites (3)
- Pharmacokinetic and pharmacodynamic investigations with vaginal devices releasing levonorgestrel at a constant, near zero order rate 1982
- Pharmacokinetic and pharmacodynamic effects of small doses of norethisterone released from vaginal rings continuously during 90 days 1979
- Pharmacokinetic and pharmacodynamic studies with vaginal devices releasing norethisterone at a constant, near zero order 1981
References (11)
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- last seen: 2026-06-10T17:14:06.276822+00:00
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- last seen: 2026-10-05T06:32:29.880811+00:00
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