A comparative study of the effects of two oral contraceptives containing dienogest or desogestrel on the human immune system

G Klinger, T Gräser, Uwe Mellinger, C. Moore, Heinz Vogelsang, Adrian Groh, Christian Latterman
In: Gynecological Endocrinology · 2000 · vol. 14(1) , pp. 15–24 · doi:10.3109/09513590009167655 · PMID:10813102 · W2160445912
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This study compared dienogest/ethinyl estradiol and desogestrel/ethinyl estradiol oral contraceptives and found differential effects on lymphocyte, monocyte, granulocyte, CD4, CD19, CD23, IgA, IgG, IgM, and serum protein levels, with neither contraceptive causing sustained immunosuppression.

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Abstract

The effects of two oral contraceptive combinations, dienogest 2.0 mg plus ethinyl estradiol 0.03 mg (Valette) and desogestrel 0.15 mg plus ethinyl estradiol 0.02 mg (Lovelle), on the human immune system were compared over one treatment cycle of 31 patients (n = 15 and n = 16, respectively). Lovelle but not Valette significantly increased the numbers of lymphocytes, monocytes and granulocytes. Valette decreased CD4 lymphocytes after 10 days' treatment; Lovelle had the opposite effect. Lovelle increased CD19 and CD23 after 21 days' treatment. Phagocytic activity was unaffected by either treatment. After 10 days' treatment, both contraceptives reduced serum IgA, IgG and IgM, which remained lowered at day 21 with Lovelle but returned to baseline with Valette. Secretory IgA was unaffected by either contraceptive. Neither treatment affected levels of interleukins, except for a significant difference between the treatment groups for interleukin-6 after 10 days' treatment that disappeared after 21 days' treatment. Levels of non-immunoglobulin serum components fluctuated; macroglobulin was increased with Valette. However, total protein and albumin levels were reduced more with Lovelle than with Valette. Complement factors also fluctuated. There was no evidence for any sustained immunosuppression with either Valette or Lovelle.

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