[Expression and significance of GLI1 and Shh in the malignant transformation of ovarian endometriosis].

Fang Zhao, F Zhao, X P Yu, Xinfeng Yu, He Zhao, H Zhao, B B Song, Bin Song, Ankang Lyu, A W Lyu, S H Zhang, L M Wang
Zhonghua fu chan ke za zhi · 2022 · vol. 57(2) , pp. 125–132 · doi:10.3760/cma.j.cn112141-20211219-00736 · PMID:35184473 · W4213172237
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This study found that high expression of GLI1 and Shh is associated with malignant transformation of ovarian endometriosis and predicts a poor prognosis in epithelial ovarian cancer patients.

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Abstract

GLI1 and Shh are highly associated with the malignant transformation of ovarian EM, which may play a role in promoting malignant degeneration of ovarian EM, and the high expression of GLI1 and Shh indicates a poor prognosis in EAOC patients.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Ovarian Neoplasms Ovarian Neoplasms Carcinoma, Ovarian Epithelial Female Hedgehog Proteins Hedgehog Proteins Humans Zinc Finger Protein GLI1 Zinc Finger Protein GLI1

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europepmc
last seen: 2026-06-12T06:13:51.797165+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:23:57.700195+00:00
License: CC0 · commercial use OK