Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms

Yangyang Zhang, Yang-Yang Zhang, Li MZ, Mao-Zhi Li, Shen HH, Hui-Hui Shen, Hui‐Hui Shen, Ayitila Abudukeyoumu, Abudukeyoumu A, Xie F, Feng Xie, Ye JF, Jiang-Feng Ye, Xu FY, Feng-Yuan Xu, Jiang‐Feng Ye, Jian-Song Sun, Sun JS, Fengyuan Xu, Jiansong Sun, Ming-Qing Li, Li MQ, Ming‐Qing Li
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023 · vol. 166 , pp. 115340 · doi:10.1016/j.biopha.2023.115340 · PMID:37625321 · W4386112412
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

This review examines how various ginsenosides combat endometrium-related diseases by inducing apoptosis, promoting autophagy, regulating EMT, and activating immunity against diseased cells.

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Abstract

Ginsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesenchymal transition (EMT) in endometrium-related cells, and activating the immune system to kill cells associated with endometrial diseases. We hope to provide a theoretical foundation for the treatment of endometrium-related diseases by ginsenosides.

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Condition tags

endometriosis

MeSH descriptors

Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (82)

Source provenance

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License: CC0 · commercial use OK