Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms

Yangyang Zhang, Yang-Yang Zhang, Mao-Zhi Li, Hui-Hui Shen, Ayitila Abudukeyoumu, Hui‐Hui Shen, Feng Xie, Jiang-Feng Ye, Jiang‐Feng Ye, Feng-Yuan Xu, Fengyuan Xu, Jian-Song Sun, Ming-Qing Li, Jiansong Sun, Ming‐Qing Li
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023 · vol. 166 , pp. 115340 · doi:10.1016/j.biopha.2023.115340 · PMID:37625321 · W4386112412
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This review examines how various ginsenosides combat endometrium-related diseases by inducing apoptosis, promoting autophagy, regulating EMT, and activating immunity against diseased cells.

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Abstract

Ginsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesenchymal transition (EMT) in endometrium-related cells, and activating the immune system to kill cells associated with endometrial diseases. We hope to provide a theoretical foundation for the treatment of endometrium-related diseases by ginsenosides.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (82)

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europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
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