Non-surgical intervention for retroperitoneal lymphogenic and pulmonary metastases of a benign leiomyoma: treatment with ulipristal acetate

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Ulipristal acetate successfully eliminated retroperitoneal and pulmonary metastases of benign leiomyoma in a patient with prior surgical failure, demonstrating an effective non-surgical intervention for this rare condition.

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Abstract

This case report describes a very rare coexistence of retroperitoneal lymphogenic and pulmonary metastases of a benign leiomyoma: benign metastasising leiomyoma (BML). Despite surgical treatment growth of multiple nodules in the lungs, omentum, mesenterium and retroperitoneum was observed by CT scan. We started off-label ulipristal acetate treatment with impressive results. The lesions on the CT scan disappeared, and the patient was asymptomatic after treatment.

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MeSH descriptors

Leiomyoma Lung Neoplasms Norpregnadienes Adult Contraceptive Agents, Female Contraceptive Agents, Female Diagnosis, Differential Female Humans Leiomyoma Leiomyoma Leiomyoma Lung Lung Lung Neoplasms Lung Neoplasms Lung Neoplasms Norpregnadienes Norpregnadienes Omentum

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europepmc
last seen: 2026-10-25T09:32:14.900964+00:00
pubmed
last seen: 2026-10-08T21:21:08.819620+00:00
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