Immunoexpression of the PTEN protein and matrix metalloproteinase-2 in endometrial cysts, endometrioid and clear cell ovarian cancer

Aleksandra Brucka, Krzysztof Szyłło
In: Polish Gynaecology · 2013 · vol. 84(5) , pp. 344–51 · doi:10.17772/gp/1587 · PMID:23819399 · W2085183608
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This study quantified PTEN and MMP-2 protein expression in endometrial cysts and ovarian cancers, finding significantly different MMP-2 immunoreactivity between groups and a correlation between PTEN/MMP-2 and obesity in endometrioid carcinomas.

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The provided text does not contain the body of a scientific paper titled "Immunoexpression of the PTEN protein and matrix metalloproteinase-2 in endometrial cysts, endometrioid and clear cell ovarian cancer." Instead, it consists of unrelated Polish snippets discussing folic acid, buckwheat honey, perinatology, vitamin B12, diet, and infant hemangiomas. Consequently, no research findings, methods, or populations can be summarized from this input. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

OBJECTIVES: Endometrioid and clear cell ovarian adenocarcinomas are suspected to derive from ectopic endometrial foci. The aim of the study was to determine PTEN and MMP-2 immunoexpression in endometrial ovarian cysts, endometrioid and clear cell ovarian carcinomas and to assess the relationship between the abovementioned values and clinical data of patients in order to find the marker of increased risk of malignant proliferation based on ovarian endometriotic lesions. Detailed analysis of the collected data was conducted to investigate the correlation between immunohistochemical expression of the examined antigens, histopathological diagnosis and clinical condition of patients. MATERIAL AND METHODS: 20 endometrial adenocarcinomas, 21 clear cell ovarian cancers and 26 endometrial cysts were included in the study The control group consisted of 29 specimens of physiological endometrium: 16 samples of the proliferative phase and 13 samples of the secretory phase. Protein expression of PTEN and MMP-2 was evaluated by immunohistochemistry Protein immunoexpression in the collected specimens was estimated with the use of light microscope and MultiScan software. Immunoreactivity of the PTEN antigen was assessed by the quantitative method, whereas MMP-2 immunoexpression was evaluated by the semi-quantitative method. Two-sided tests were used for statistical inference. Generalized linear models were used to compare the studied groups. Error distributions were selected using the Akaike criterion (AIC). Statistical analysis was conducted with the use of the R Statistical Package. RESULTS: MMP-2 immunoreactivity differed significantly between the study groups and controls (p<0.001). PTEN immunoexpression was the strongest in endometrial cysts (53.7 %), lower in clear cell cancers (50.2%) and the lowest in endometrioid adenocarcinomas (43.88%), but the differences were not statistically significant (p=0.17). PTEN reactivity in the group of endometrioid carcinomas was significantly higher (p=0.02), while MMP-2 expression had a falling tendency (p=0.076) in obese women. CONCLUSIONS: Increased MMP-2 expression in the successive groups may imply a rising invasive potential of the epithelial cells in endometrial cysts, endometrioid and clear cell adenocarcinomas. Strong immunoreactivity for PTEN in proliferative endometrium implies its role in the regulation of endometrial proliferation. PTEN activity may reduce MMP-2 expression in insulin resistant women suffering from endometrial ovarian cancer Simultaneous evaluation of PTEN and MMP-2 immunoexpression in ectopic endometrial foci cannot be used to identify women with an increased risk of neoplastic transformation.
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Kwas foliowy: dawkowanie, źródła w diecie i objawy niedoboru Kwas foliowy, który powszechnie znany jest jako witamina B9, odgrywa kluczową rolę w moim zdrowiu oraz samopoczuciu. Ponadto, to jedna z tych substanc... Kwas foliowy, który powszechnie znany jest jako witamina B9, odgrywa kluczową rolę w moim zdrowiu oraz samopoczuciu. Ponadto, to jedna z tych substanc... Miód gryczany to prawdziwy skarb natury, który dostarcza nam wielu korzyści w diecie. Nie tylko urzeka intensywnym smakiem, ale także stanowi bogate ź... Perinatolog, jako specjalista, pełni kluczową rolę w zapewnieniu bezpieczeństwa zarówno matce, jak i dziecku podczas ciąży wysokiego ryzyka. Jako gine... Witam serdecznie! Zawsze zastanawiam się, jak istotna dla naszego organizmu jest witamina B12. Odpowiada ona za prawidłowe funkcjonowanie układu nerwo... Od zawsze zdawałam sobie sprawę z ważności dbania o zdrowie, jednak odkąd zgłębiam tajniki zrównoważonej diety, odkryłam, że ... Objawy naczyniaka włośniczkowego u dzieci stanowią temat, który niejedną mamę może zaniepokoić. Te charakterystyczne czerwone... Perinatolog, jako specjalista, pełni kluczową rolę w zapewnieniu bezpieczeństwa zarówno matce, jak i dziecku podczas ciąży wy... Grażyna Patec

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