Impact of ovarian hyperstimulation syndrome on intracytoplasmic sperm injection outcomes in poly-cystic ovarian syndrome women: A cross-sectional study.

Jwad MA, Khaleefah MH, Naser RAA
International journal of reproductive biomedicine · 2025 · doi:10.18502/ijrm.v23i2.18496 · PMID:40371358 · PMC12070050
OA: gold CC-BY-NC-4.0
📄 Open PDF Full text JSON View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-29 ⓘ

Ovarian hyperstimulation syndrome in PCOS women undergoing ICSI was associated with differences in stimulation duration and oocyte yield but not embryo quality or pregnancy rates.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-10 · read from full text ⓘ

This cross-sectional study analyzed data from 84 women with polycystic ovarian syndrome undergoing intracytoplasmic sperm injection to determine if ovarian hyperstimulation syndrome negatively impacts reproductive outcomes. The participants were divided into groups based on the presence or absence of OHSS, revealing that while the OHSS group had significantly more retrieved oocytes and a shorter stimulation duration, there were no significant differences in fertilization rates, embryo quality, or pregnancy outcomes compared to the non-OHSS group. The authors note that although high estradiol levels are associated with OHSS development, these elevated levels did not translate to poorer embryo viability or lower success rates in this cohort. Relevance to endometriosis: excluded as an inclusion criterion for participants; therefore, the paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

BackgroundPolycystic ovarian syndrome (PCOS) is a complex disorder that affects the endocrine, metabolic, and reproductive systems. While controlled ovarian hyperstimulation can increase the number of oocytes retrieved and improve the number of good-quality embryos, it may also negatively affect oocyte maturity, embryo quality, endometrial receptivity, and pregnancy outcomes.ObjectiveThis study aimed to find out if ovarian hyperstimulation syndrome (OHSS) has negative effects on intracytoplasmic sperm injection outcomes in a sample of PCOS women.Materials and methodsIn this cross-sectional study, data of 84 PCOS women who underwent controlled ovarian stimulation using a flexible antagonist protocol-treated intracytoplasmic sperm injection cycles referred to the Infertility Department of Higher Institute for the Diagnosis of Infertility and Assisted Reproduction Techniques, Baghdad, Iraq between January 2020 and December 2023 was extracted from their medical records. Participants were categorized into 2 groups after undergoing controlled ovarian hyperstimulation protocol: PCOS with OHSS (n = 54) and PCOS without OHSS (n = 30). The dosage was tailored based on age, body mass index, and response to previous stimulation cycles, if applicable. The trigger was administered using decapeptyl 0.2 mg alone or in combination with recombinant human chorionic gonadotrophin, depending on the estradiol levels at the time of the trigger.ResultsSignificant differences were observed in the duration of stimulation (p = 0.005), oocyte yield (p = 0.001), mature oocytes (p = 0.001), and fertilized oocytes (p = 0.036); however, no significant difference was observed, neither in number of good quality embryos (p = 0.52) nor in pregnancy rate (p = 0.54) after fresh and frozen embryo transfer between the 2 groups.ConclusionOHSS does not affect the embryo quality or pregnancy rate in PCOS women.
Full text 16,887 characters · extracted from pmc-nxml · 2 sections · click to expand

Section

MA. Jwad: Conceptualization and data curation. MH. Khaleefah: Formal analysis and data curation. R. Abd AlFattah Naser: Investigation.

Coi Statement

The authors declare that there is no conflict of Interest.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: pmc-nxml ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

europepmc
last seen: 2026-09-20T09:27:46.357103+00:00
unpaywall
last seen: 2026-05-21T05:10:58.409756+00:00
License: CC-BY-NC-4.0