Clinical efficacy of laparoscopic surgery combined with drug therapy for endometriosis: A meta-analysis

Meng Jiang, Jiang M, Wenxiao Hou, Hou W, Yu T, Changyuan Yu, Tao Yu
Medical engineering & physics · 2022 · vol. 107(1) , pp. 103866 · doi:10.1016/j.medengphy.2022.103866 · PMID:36068035 · W4292550238
Systematic review / meta-analysis OA: closed CC0 ⤵ 1 in-corpus citation
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Laparoscopic surgery combined with drug therapy for endometriosis showed higher efficacy, pregnancy rates, and lower recurrence and adverse reaction rates compared to surgery alone.

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Abstract

OBJECTIVE: To systematically investigate the clinical efficacy and prognosis of laparoscopic surgery combined with drug therapy for endometriosis. METHODS: Clinical randomized controlled trials regarding laparoscopic surgery combined with drug therapy for endometriosis and published between 2010 and 2022 were retrieved from PubMed, Web of Science and Embase, China National Knowledge Infrastructure, and Wanfang databases. Meta-analysis and sensitivity tests were performed using the Stata16.0 software. RESULTS: A total of 1332 articles were retrieved. Of them, 11 studies were included for final analysis, comprising of 521 cases in the treatment group (laparoscopic surgery combined with drug therapy) and 530 cases in the control group (laparoscopic surgery alone). Meta-analysis results showed that compared with the control group, the combined treatment had higher treatment effective rate [OR = 4.542, 95% CI (3.062, 6.736), P < 0.001], pregnancy rate [OR = 3.341, 95% CI (2.336, 4.780), P < 0.001], and lower incidence of adverse reactions [OR = 0.348, 95% CI (0.208, 0.583), P < 0.001] and recurrence rate [OR = 0.187, 95% CI (0.106, 0.328), P < 0.001]. In addition, after treatment, estradiol [SMD = -3.417, 95% CI (-4.631, -2.203), P < 0.001] and follicle-stimulating hormone [SMD = -1.976, 95% CI (-3.202, -0.751), P = 0.002] in the treatment group were significantly lower than the control group. CONCLUSION: Compared with laparoscopic surgery alone, laparoscopic surgery combined with drug therapy demonstrated better clinical efficacy and improved postoperative infertility and recurrence rate for treating endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (14)

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