Clinical efficacy of laparoscopic surgery combined with drug therapy for endometriosis: A meta-analysis

Meng Jiang, Jiang M, Wenxiao Hou, Hou W, Yu T, Changyuan Yu, Tao Yu
Medical engineering & physics · 2022 · vol. 107(1) , pp. 103866 · doi:10.1016/j.medengphy.2022.103866 · PMID:36068035 · W4292550238
Systematic review / meta-analysis OA: closed CC0 ⤵ 1 in-corpus citation
Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Laparoscopic surgery combined with drug therapy for endometriosis showed higher efficacy, pregnancy rates, and lower recurrence and adverse reaction rates compared to surgery alone.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-11-02 · read from full text ⓘ

This meta-analysis evaluated the clinical efficacy of combining laparoscopic surgery with drug therapy versus laparoscopic surgery alone for treating endometriosis. The review included eleven randomized controlled trials involving over one thousand patients, analyzing outcomes such as treatment effectiveness, pregnancy rates, recurrence, and hormone levels. Results indicated that the combined approach significantly improved postoperative pregnancy rates and reduced both adverse reactions and disease recurrence compared to surgical intervention alone. This paper is centrally about endometriosis — specifically comparing surgical and pharmacological management strategies for the condition.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

OBJECTIVE: To systematically investigate the clinical efficacy and prognosis of laparoscopic surgery combined with drug therapy for endometriosis. METHODS: Clinical randomized controlled trials regarding laparoscopic surgery combined with drug therapy for endometriosis and published between 2010 and 2022 were retrieved from PubMed, Web of Science and Embase, China National Knowledge Infrastructure, and Wanfang databases. Meta-analysis and sensitivity tests were performed using the Stata16.0 software. RESULTS: A total of 1332 articles were retrieved. Of them, 11 studies were included for final analysis, comprising of 521 cases in the treatment group (laparoscopic surgery combined with drug therapy) and 530 cases in the control group (laparoscopic surgery alone). Meta-analysis results showed that compared with the control group, the combined treatment had higher treatment effective rate [OR = 4.542, 95% CI (3.062, 6.736), P < 0.001], pregnancy rate [OR = 3.341, 95% CI (2.336, 4.780), P < 0.001], and lower incidence of adverse reactions [OR = 0.348, 95% CI (0.208, 0.583), P < 0.001] and recurrence rate [OR = 0.187, 95% CI (0.106, 0.328), P < 0.001]. In addition, after treatment, estradiol [SMD = -3.417, 95% CI (-4.631, -2.203), P < 0.001] and follicle-stimulating hormone [SMD = -1.976, 95% CI (-3.202, -0.751), P = 0.002] in the treatment group were significantly lower than the control group. CONCLUSION: Compared with laparoscopic surgery alone, laparoscopic surgery combined with drug therapy demonstrated better clinical efficacy and improved postoperative infertility and recurrence rate for treating endometriosis.
Full text 2,189 characters · extracted from oa-doi-fallback · 4 sections · click to expand

Abstract

Objective To systematically investigate the clinical efficacy and prognosis of laparoscopic surgery combined with drug therapy for endometriosis.

Methods

Clinical randomized controlled trials regarding laparoscopic surgery combined with drug therapy for endometriosis and published between 2010 and 2022 were retrieved from PubMed, Web of Science and Embase, China National Knowledge Infrastructure, and Wanfang databases. Meta-analysis and sensitivity tests were performed using the Stata16.0 software.

Results

A total of 1332 articles were retrieved. Of them, 11 studies were included for final analysis, comprising of 521 cases in the treatment group (laparoscopic surgery combined with drug therapy) and 530 cases in the control group (laparoscopic surgery alone). Meta-analysis results showed that compared with the control group, the combined treatment had higher treatment effective rate [OR = 4.542, 95% CI (3.062, 6.736), P < 0.001], pregnancy rate [OR = 3.341, 95% CI (2.336, 4.780), P < 0.001], and lower incidence of adverse reactions [OR = 0.348, 95% CI (0.208, 0.583), P < 0.001] and recurrence rate [OR = 0.187, 95% CI (0.106, 0.328), P < 0.001]. In addition, after treatment, estradiol [SMD = −3.417, 95% CI (−4.631, −2.203), P < 0.001] and follicle-stimulating hormone [SMD = −1.976, 95% CI (−3.202, −0.751), P = 0.002] in the treatment group were significantly lower than the control group.

Conclusion

Compared with laparoscopic surgery alone, laparoscopic surgery combined with drug therapy demonstrated better clinical efficacy and improved postoperative infertility and recurrence rate for treating endometriosis. Access this article The computer you are using is not registered by an institution with a subscription to this article. Please choose one of the options below.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (14)

Cited by (1)

Source provenance

europepmc
last seen: 2026-11-09T06:14:10.326338+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:36:33.795939+00:00
unpaywall
last seen: 2026-11-09T06:31:04.326590+00:00
License: CC0 · commercial use OK