Effect of medical treatment of endometriosis after hysteroscopy combined with laparoscopy operation

Dan Wang

doi:10.3877/cma.j.issn.1673-5250.2015.05.017

Effect of medical treatment of endometriosis after hysteroscopy combined with laparoscopy operation

Dan Wang

In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2015 · vol. 11(5) , pp. 629–633 · doi:10.3877/cma.j.issn.1673-5250.2015.05.017 · W3029425368

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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Gestrinone and triptorelin treatments after hysteroscopy and laparoscopy for endometriosis showed similar effectiveness in pregnancy and recurrence rates, but gestrinone had a lower adverse reaction rate.

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This randomized study investigated postoperative medical treatment effects in 128 patients with endometriosis who underwent hysteroscopy combined with laparoscopy, comparing triptorelin (n=64) versus gestrinone (n=64). Outcomes included pregnancy rate, recurrence rate, dysmenorrhea scores, serum CA125 levels, and drug adverse reactions. After treatment, both groups showed significant within-group improvements in dysmenorrhea and CA125, while between-group comparisons after treatment found no significant differences in dysmenorrhea scores or CA125 levels; pregnancy and recurrence rates were also not significantly different. The paper explicitly notes no general-condition baseline differences, but it does not report follow-up duration details in the provided text, which may limit interpretation of recurrence. This paper is centrally about endometriosis — it compares two postoperative hormonal regimens (triptorelin vs gestrinone) after combined hysteroscopic and laparoscopic surgery.

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Abstract

Objective To study the medical treatment effect of endometriosis (EMS) after hysteroscopy combined with laparoscopy operation. Methods From June 2010 to January 2013, 128 patients with EMS in Xinhua Hospital of Hubei Province were included in the study. They were randomly divided into observation group(n=64, use gestrinone after operation) and control group(n=64, use triptorelin after operation). There were no significant differences in general condition such as age, duration of disease, stage and so on between two groups(P>0.05). The pregnancy rate, recurrence rate, dysmenorrhea points, serum CA125 level and drug adverse reaction rate were observed. Results There were no significant difference in pregnancy rate(26.6% vs 25.0%) and recurrence rate(14.1% vs 10.9%)between two groups(P>0.05). There were significant differences in dysmenorrhea points[(9.3±1.1) points vs (4.2±0.7) points, (9.1±1.0) points vs (4.3±0.6) points] and serum CA125 level[(139.4±27.2) U/mL vs (31.1±7.3) U/mL, (133.7±26.9) U/mL vs (35.4±8.1) U/mL] between before and after treatment in both groups(q=5.182, 6.086, 10.282, 13.048; P 0.05). The drug adverse reaction rate in observation group (28.1%) was obviously lower than that of control group (42.2%), and there was significant difference(q=6.296, P<0.05). Conclusions There was a considerable effect through gestrinone and triptorelin after laparoscopic and hysteroscopic surgery for patients with EMS. But during treatment, women who used triptorelin had lower drug adverse reaction than who used gestrinone. Key words: Endometriosis; Hysteroscopy; Laparoscopy; Drug therapy

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Objective

To study the medical treatment effect of endometriosis (EMS) after hysteroscopy combined with laparoscopy operation.

Methods

From June 2010 to January 2013, 128 patients with EMS in Xinhua Hospital of Hubei Province were included in the study. They were randomly divided into observation group(n=64, use gestrinone after operation) and control group(n=64, use triptorelin after operation). There were no significant differences in general condition such as age, duration of disease, stage and so on between two groups(P>0.05). The pregnancy rate, recurrence rate, dysmenorrhea points, serum CA125 level and drug adverse reaction rate were observed.

Results

There were no significant difference in pregnancy rate(26.6% vs 25.0%) and recurrence rate(14.1% vs 10.9%)between two groups(P>0.05). There were significant differences in dysmenorrhea points[(9.3±1.1) points vs (4.2±0.7) points, (9.1±1.0) points vs (4.3±0.6) points] and serum CA125 level[(139.4±27.2) U/mL vs (31.1±7.3) U/mL, (133.7±26.9) U/mL vs (35.4±8.1) U/mL] between before and after treatment in both groups(q=5.182, 6.086, 10.282, 13.048; P<0.01). But no significant differences were found in dysmenorrhea points[(4.2±0.7) points vs (4.3±0.6) points] and serum CA125 level [(31.1±7.3) U/mL vs (35.4±8.1) U/mL) ]between two groups after treatment(q=0.128, 1.734; P>0.05). The drug adverse reaction rate in observation group (28.1%) was obviously lower than that of control group (42.2%), and there was significant difference(q=6.296, P<0.05).

Conclusions

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