Magnetic resonance imaging evaluation of gynecological mass lesions: A comprehensive analysis with histopathological correlation

Syed Ahmed Salman, Syed Salman, Nabeela Shireen, Romana Riyaz, Sajjad Ahmed Khan, Janender Pal Singh, Anuj Uttam
Medicine · 2024 · vol. 103(32) , pp. e39312 · doi:10.1097/md.0000000000039312 · PMID:39121288 · PMC11315570 · W4401451894
article OA: gold CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study correlated MRI findings with histopathology in 60 patients, identifying 37 benign (most common: fibroids) and 23 malignant masses (most common: cervical cancer) and evaluating MRI's accuracy in diagnosing specific gynecological lesions.

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Abstract

Evaluating gynecological mass lesions and reviewing their morphological characteristics based on their imaging appearance on magnetic resonance imaging (MRI), and correlating the MRI findings with histopathological findings, was the central theme of our study. This observational cross-sectional study was conducted on 60 female patients with clinically suspected gynecological mass lesions upon physical examination and/or ultrasonography, referred for MRI at a tertiary care hospital over a 1-year period between June 2022 and July 2023. A broad spectrum of differential diagnoses of gynecological masses was observed. In our study, the ratio of benign versus malignant disease was 1.6:1, with 37 benign and 23 malignant masses identified. The most common benign masses were uterine fibroids (n = 14; 23.3%), followed by endometriosis (n = 8; 13.3%), and ovarian dermoid cysts (n = 4; 6.6%). Among the malignant lesions, cervical cancer was the most common (n = 11; 18.3%), followed by endometrial carcinoma (n = 7; 11.6%), ovarian carcinoma (n = 3; 5%), and vaginal carcinoma (n = 2; 3%). Benign lesions mostly appeared hypo- to isointense on T1-weighted imaging and iso- to hyperintense on T2-weighted imaging, while malignant lesions appeared isointense on T1-weighted and hyperintense on T2-weighted imaging. Hemorrhage and fat were well appreciated on MRI and aided in diagnosis. T2 shading was present in 7 out of 8 endometriotic cysts, demonstrating a specificity of 100% and a sensitivity of 83%. For determining parametrial invasion in cervical carcinoma, MRI showed an accuracy of 91%, specificity of 100%, and positive predictive value, negative predictive value, and sensitivity of 100%, 75%, and 88%, respectively. In cases of endometrial carcinoma, MRI demonstrated a sensitivity and specificity of 87% and 91%, respectively, with a positive predictive value of 87% and a negative predictive value of 91% for identifying myometrial invasion greater than 50%. Compared to other modalities, MRI provided substantial information regarding uterine and adnexal masses and surrounding structures, facilitating accurate staging of lesions.

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Condition tags

endometriosis

MeSH descriptors

Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Adult Adult Adult Adult Adult Adult Adult

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