Evaluation of peritoneal fluid hemosiderin-laden macrophages in biopsy-proven endometriosis

Mohamed Ali Bedaiwy, Mohamed A. Bedaiwy, Javier Noriega, Noriega J, Mahmoud Abdel Aleem, Abdel Aleem M, Gupta S, Sajal Gupta, A Abul-Hassan, AbulHassan AM, Ahmed M AbulHassan, Brainard J, Jennifer Brainard, Ismail AM, Alaa Ismail, Alaa M Ismail, Falcone T, Tommaso Falcone
Analytical and quantitative cytology and histology · 2012 · vol. 34(1) , pp. 23–7 · PMID:22590816 · W63542803
Diagnostic accuracy OA: closed CC0 ⤵ 9 in-corpus citations
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This study found that hemosiderin-laden macrophages were significantly more common in the peritoneal fluid of endometriosis patients, exhibiting 52% sensitivity and 87% specificity for diagnosis.

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Abstract

OBJECTIVE: To evaluate peritoneal fluid hemosiderin-laden macrophages (H-LMs) in patients with endometriosis compared to controls. STUDY DESIGN: Consecutive series of 46 patients during a year undergoing laparoscopy for benign gynecologic conditions were included. The presence of H-LMs in peritoneal fluid was evaluated. We compared clinical factors in patients with or without endometriosis in respect to H-LM status. To assess the potential of H-LMs to diagnose endometriosis, the sensitivity and specificity were calculated. RESULTS: Patients with endometriosis were significantly more likely to have positive H-LM test results than controls (p = 0.0013). The presence of H-LM has a low sensitivity of 52% but an acceptable specificity of 87% in diagnosing endometriosis. The presence of H-LMs was not related with any other of the clinical factors studied. CONCLUSION: The presence of specific findings of H-LMs related to endometriosis strongly suggests abnormalities in peritoneal iron metabolism.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Hemosiderin Macrophages Adult Adult Ascitic Fluid Ascitic Fluid Biopsy Biopsy Endometriosis Endometriosis Endometriosis Female Female Hemosiderin Hemosiderin Humans Humans Macrophages

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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