Evaluation of peritoneal fluid hemosiderin-laden macrophages in biopsy-proven endometriosis.

Mohamed Ali Bedaiwy, Mohamed A. Bedaiwy, Javier Noriega, Noriega J, Mahmoud Abdel Aleem, Abdel Aleem M, Gupta S, Sajal Gupta, A Abul-Hassan, AbulHassan AM, Ahmed M AbulHassan, Brainard J, Jennifer Brainard, Ismail AM, Alaa Ismail, Alaa M Ismail, Falcone T, Tommaso Falcone
Analytical and quantitative cytology and histology · 2012 · vol. 34(1) , pp. 23–7 · PMID:22590816 · W63542803
article OA: closed CC0 ⤵ 9 in-corpus citations
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This study found that hemosiderin-laden macrophages were significantly more common in the peritoneal fluid of endometriosis patients, exhibiting 52% sensitivity and 87% specificity for diagnosis.

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Abstract

OBJECTIVE: To evaluate peritoneal fluid hemosiderin-laden macrophages (H-LMs) in patients with endometriosis compared to controls. STUDY DESIGN: Consecutive series of 46 patients during a year undergoing laparoscopy for benign gynecologic conditions were included. The presence of H-LMs in peritoneal fluid was evaluated. We compared clinical factors in patients with or without endometriosis in respect to H-LM status. To assess the potential of H-LMs to diagnose endometriosis, the sensitivity and specificity were calculated. RESULTS: Patients with endometriosis were significantly more likely to have positive H-LM test results than controls (p = 0.0013). The presence of H-LM has a low sensitivity of 52% but an acceptable specificity of 87% in diagnosing endometriosis. The presence of H-LMs was not related with any other of the clinical factors studied. CONCLUSION: The presence of specific findings of H-LMs related to endometriosis strongly suggests abnormalities in peritoneal iron metabolism.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Hemosiderin Macrophages Adult Ascitic Fluid Biopsy Endometriosis Endometriosis Female Hemosiderin Humans Macrophages Macrophages Sensitivity and Specificity

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