MORPHOMETRIC STUDY OF STRUCTURAL CHANGES IN VESSELS OF THE HEMOMICROCIRCULATORY BED OF THE URINARY BLADDER AT POSTRESECTION PORTAL HYPERTENSION

The study used morphometric analysis of bladder hemomicrocirculation in 22 mature male Vietnamese pigs, comparing intact controls with animals modeled by left/right liver lobe resection (60.5% liver volume) to create postresection portal hypertension, and with a subgroup that developed postresection portal hypertension plus multiple organ failure. One month after modeling, the authors report narrowing of bladder arterioles, precapillary arterioles, and hemocapillaries with thickened vessel walls, alongside dilation of postcapillary venules and venules with thinning of their walls, and associated hypoxia and epithelial, myocyte, endothelial, and connective tissue alterations including apoptotic and dystrophic changes, cellular infiltration, and stromal proliferation; changes were more severe with combined portal hypertension and multiple organ failure. The paper’s main limitation is that it is an animal morphological model focused on one post-injury timepoint (30 days) without mechanistic testing beyond quantitative morphometry. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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