Endocannabinoids as markers of sperm quality: hot spots

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This review discusses how endocannabinoids like anandamide regulate sperm motility and fertilization via CB1 and TRPV1 receptors, proposing their measurement as a diagnostic tool for male infertility.

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This review examines the endocannabinoid system, specifically CB1 and TRPV1 receptors and their ligands anandamide and 2-AG, as critical regulators of human sperm quality and fertilizing ability. The paper details how these receptors influence sperm motility, energy metabolism, acrosome reaction, and chromatin integrity, noting that altered levels of endocannabinoids in seminal plasma correlate with male infertility parameters such as asthenozoospermia. While the primary focus is on male reproductive biology and potential diagnostic biomarkers for infertility, the text briefly mentions that TRPV1 generates hyperalgesia via primary sensory neurons during endometriosis. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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References

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Keywords

cholesterol, chromatin, epigenetic regulation, lipid rafts, receptors Citation Maccarrone M (2013) Endocannabinoids as Markers of Sperm Quality: Hot Spots. Front. Endocrinol. 4:169. doi: 10.3389/fendo.2013.00169 Received 24 October 2013 Accepted 24 October 2013 Published 08 November 2013 Volume 4 - 2013 Edited by Riccardo Pierantoni, Seconda Università di Napoli, Italy Copyright © 2013 Maccarrone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. *Correspondence: [email protected] This article was submitted to Experimental Endocrinology, a section of the journal Frontiers in Endocrinology. Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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