Endocannabinoids as markers of sperm quality: hot spots
This review discusses how endocannabinoids like anandamide regulate sperm motility and fertilization via CB1 and TRPV1 receptors, proposing their measurement as a diagnostic tool for male infertility.
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This review examines the endocannabinoid system, specifically CB1 and TRPV1 receptors and their ligands anandamide and 2-AG, as critical regulators of human sperm quality and fertilizing ability. The paper details how these receptors influence sperm motility, energy metabolism, acrosome reaction, and chromatin integrity, noting that altered levels of endocannabinoids in seminal plasma correlate with male infertility parameters such as asthenozoospermia. While the primary focus is on male reproductive biology and potential diagnostic biomarkers for infertility, the text briefly mentions that TRPV1 generates hyperalgesia via primary sensory neurons during endometriosis. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.
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- europepmc
- last seen: 2026-11-01T09:25:17.647243+00:00
- pubmed
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