The effect of chronic gonadotropin-releasing hormone analog (D-Trp-6) treatment on elevated and normal serum prolactin levels

A. Golan, Abraham Golan, Ian Bukovsky, I Bukovsky, Z. Weinraub, Raphaël Ron-El, R. Ron-El, A Herman, Arie Herman, A. Raziel, Arié Raziel, Eliahu Caspi, E Caspi
Fertility and sterility · 1989 · vol. 51(3) , pp. 532–534 · doi:10.1016/s0015-0282(16)60570-8 · PMID:2522065 · W2415846637
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This study investigated the impact of chronic GnRH analog (D-Trp-6) treatment on both elevated and normal serum prolactin levels in patients.

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Abstract

A long-acting GnRHa (D-Trp-6 microcapsules) proved capable of lowering serum PRL levels in a young hyperprolactinemic patient treated for a large myomatous uterus. No similar inhibitory effect was found in normoprolactinemia. Chronic GnRHa therapy may constitute an alternative to the existing forms of treatment for hyperprolactinemia and pituitary adenomas.

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MeSH descriptors

Antineoplastic Agents Gonadotropin-Releasing Hormone Hyperprolactinemia Leiomyoma Uterine Neoplasms Adult Antineoplastic Agents Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Hyperprolactinemia Hyperprolactinemia Leiomyoma Leiomyoma Triptorelin Pamoate Uterine Neoplasms Uterine Neoplasms

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