Downregulation of FOXO1 mRNA levels predicts treatment failure in patients with endometrial pathology conservatively managed with progestin-containing intrauterine devices

Henry Reyes Pineda; Matthew J. Carlson; Eric J. Devor; Yuping Zhang; Kristina W. Thiel; Megan I. Samuelson; Megan McDonald; Shujie Yang; Jean-Marie Stephan; Erica Savage; Donghai Dai; Michael J. Goodheart; Kimberly K. Leslie

doi:10.1016/j.ygyno.2015.10.023

Downregulation of FOXO1 mRNA levels predicts treatment failure in patients with endometrial pathology conservatively managed with progestin-containing intrauterine devices

Henry Reyes Pineda, Matthew J. Carlson, Eric J. Devor, Yuping Zhang, Kristina W. Thiel, Megan I. Samuelson, Megan McDonald, Shujie Yang, Jean-Marie Stephan, Erica Savage, Donghai Dai, Michael J. Goodheart, Kimberly K. Leslie

In: Gynecologic Oncology · 2015 · vol. 140(1) , pp. 152–160 · doi:10.1016/j.ygyno.2015.10.023 · PMID:26524723 · W1941055066

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This study found that reduced FOXO1 mRNA levels can predict treatment failure in patients with endometrial pathology managed conservatively using progestin-releasing intrauterine devices.

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[1] LNG-IUS versus oral progestogen treatment for endometrial hyperplasia: a long-term comparative cohort study 2013

[2] Prediction of Regression and Relapse of Endometrial Hyperplasia With Conservative Therapy 2013