[Endometriosis and discouragement of immunology cytotoxic characteristics]

Hernández Guerrero CA, César Angel Hernández Guerrero, César Ángel Hernández Guerrero, Rubén Tlapanco Barba, Tlapanco Barba R, Ramos Pérez C, Carlos Ramos Pérez, Velázquez Ramírez N, Norma Velázquez Ramírez, Denisse Castro-Eguiluz, Denisse Castro Eguiluz, Arturo Cérbulo Vázquez, Cérbulo Vázquez A
Ginecologia y obstetricia de Mexico · 2003 · vol. 71 , pp. 559–74 · PMID:15228015 · W2408190024
Observational OA: closed CC0 ⤵ 8 in-corpus citations
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Endometriosis patients exhibit a reduced cytotoxic immune response in their peritoneal environment, characterized by decreased T cell and NK cell activity, which worsens with disease severity.

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Abstract

OBJECTIVE: To determine the immunology kind of response Th1 (cytotoxic) or Th2 (humoral) prevailing at peripheral and peritoneal environment at endometriosis women (ENW). STUDY DESIGN: Observational, transverse, analytical, retrospective, cases and controls. MATERIAL AND METHODS: Cooperative and cytotoxic lymphocytes obtained from peritoneal fluid (PF) and peripheral blood (PB) were used to determine IFN-gamma and IL-2 intracellular synthesis at ENW. IFN-gamma, IL-2, IL-4 and IL-10 concentration were determined at PF, PB at ENW and fertile women (FERW). Results were analyzed by ANOVA, t student and Mann-Whitney tests, accepting p < 0.05, as a statistic difference. RESULTS: Peritoneal environment of ENW shows a smaller intracellular synthesis of IFN-gamma and IL-2 at cooperative and cytotoxic T lymphocytes, as in the PF at ENW. The decrease is associated to a smaller percentage of activated, cooperative T lymphocytes and NK cells (p < 0.05, at all the variable), versus FERW. This phenomenon is observed more stressed at the III and IV pathology degree. CONCLUSIONS: ENW show a peritoneal environment with a smaller immunology cytotoxic capacity, versus FERW. The discouragement of the immunology cytotoxic capacity increases associated to the pathology intensity.

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Condition tags

endometriosis

MeSH descriptors

Cytotoxicity, Immunologic Cytotoxicity, Immunologic Endometriosis Genital Diseases, Female Case-Control Studies Case-Control Studies Cross-Sectional Studies Cross-Sectional Studies Endometriosis Endometriosis Female Female Genital Diseases, Female Genital Diseases, Female Humans Humans Retrospective Studies Retrospective Studies T-Lymphocytes T-Lymphocytes

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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