[Endometriosis and discouragement of immunology cytotoxic characteristics].

César Angel Hernández Guerrero, César Ángel Hernández Guerrero, Rubén Tlapanco Barba, Carlos Ramos Pérez, Norma Velázquez Ramírez, Denisse Castro Eguiluz, Denisse Castro-Eguiluz, Arturo Cérbulo Vázquez
Ginecologia y obstetricia de Mexico · 2003 · vol. 71 , pp. 559–74 · PMID:15228015 · W2408190024
article OA: closed CC0 ⤵ 8 in-corpus citations
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Endometriosis patients exhibit a reduced cytotoxic immune response in their peritoneal environment, characterized by decreased T cell and NK cell activity, which worsens with disease severity.

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Abstract

OBJECTIVE: To determine the immunology kind of response Th1 (cytotoxic) or Th2 (humoral) prevailing at peripheral and peritoneal environment at endometriosis women (ENW). STUDY DESIGN: Observational, transverse, analytical, retrospective, cases and controls. MATERIAL AND METHODS: Cooperative and cytotoxic lymphocytes obtained from peritoneal fluid (PF) and peripheral blood (PB) were used to determine IFN-gamma and IL-2 intracellular synthesis at ENW. IFN-gamma, IL-2, IL-4 and IL-10 concentration were determined at PF, PB at ENW and fertile women (FERW). Results were analyzed by ANOVA, t student and Mann-Whitney tests, accepting p < 0.05, as a statistic difference. RESULTS: Peritoneal environment of ENW shows a smaller intracellular synthesis of IFN-gamma and IL-2 at cooperative and cytotoxic T lymphocytes, as in the PF at ENW. The decrease is associated to a smaller percentage of activated, cooperative T lymphocytes and NK cells (p < 0.05, at all the variable), versus FERW. This phenomenon is observed more stressed at the III and IV pathology degree. CONCLUSIONS: ENW show a peritoneal environment with a smaller immunology cytotoxic capacity, versus FERW. The discouragement of the immunology cytotoxic capacity increases associated to the pathology intensity.

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Condition tags

endometriosis

MeSH descriptors

Cytotoxicity, Immunologic Endometriosis Genital Diseases, Female Case-Control Studies Cross-Sectional Studies Endometriosis Female Genital Diseases, Female Humans Retrospective Studies T-Lymphocytes T-Lymphocytes

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