[Study on polymorphism of human leukocyte antigen I in patients with endometriosis]
Observational
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⤵ 9 in-corpus citations
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This study found a higher frequency of HLA-I B46 and a lower frequency of HLA-I B48 in endometriosis patients compared to controls.
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Abstract
OBJECTIVE: To study the possibility of a correlation between polymorphism of human leukocyte antigen (HLA)-I antigen and occurrence of endometriosis (Em).
METHODS: Polymorphism of HLA-I A and B locations were detected by mini-lymphocytotoxin test in 40 surgically proven Em patients and 50 normal controls. The frequency of different antigens on both A and B sites were compared between the 2 groups.
RESULTS: No significant difference of the antigen frequency at HLA-I A site was shown between Em and control groups. However, at HLA-I B site, frequency of B46 antigen in Em group was significantly higher [33% Vs 16%, P < 0.05, relative risk (RR) 2.5278] and frequency of B48 antigen in Em group was significantly lower (3% Vs 16% P < 0.05, RR 0.1346) as compared with those of the controls.
CONCLUSIONS: The occurrence of Em may be associated with the presence of HLA-I B46 antigen. On the contrary, the HLA-I B48 antigen might play a protective role against Em.
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Cited by (9)
- Endometriosis Research: From Bench to Bedside 2022
- Endometriosis diagnosis and medical treatment: Present and future 2021
- Genetic Characterization of Endometriosis Patients: Review of the Literature and a Prospective Cohort Study on a Mediterranean Population 2020
- Killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen-C (HLA-C) allorecognition patterns in women with endometriosis 2020
- Molecular aspects of endometriosis 2015
- Molecular aspects of development and regulation of endometriosis 2014
- Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis 2008
- Endometriosis and genetic polymorphisms 2007
- Susceptibility to ovarian endometriosis in Polish population is not associated with HLA-DRB1 alleles 2005
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- europepmc
- last seen: 2026-10-17T06:09:56.316927+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-10-08T21:00:15.595027+00:00
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