Endometrioma için biyobelirteç olarak immatür granülosit yüzdesi

Aim: This study aims to investigate the potential of immature granulocyte percentage as a predictive biomarker for endometrioma in patients undergoing cystectomy for benign ovarian cysts. Methods: This retrospective study was conducted at the Department of Obstetrics and Gynaecology, Mersin University Faculty of Medicine Hospital, between 2004 and 2024. A total of 358 patients who underwent oophorectomy due to benign ovarian cysts were included in the study. Demographic characteristics, laboratory parameters, and surgical details were collected. The diagnosis of endometrioma was confirmed by histopathological examination of surgical specimens evaluated by experienced pathologists. Results: Of the 358 patients included, 144 (40.2%) were diagnosed with endometrioma, 22 (6.1%) with haemorrhagic cystadenoma, 138 (38.5%) with serous cystadenoma, and 54 (15.1%) with mucinous cystadenoma. The most common symptom in the endometrioma group was chronic pelvic pain (62.5%), followed by dysmenorrhea (34%) and dyspareunia (3.5%). Infertility was significantly more common in the endometrioma group (72.9%) compared to other groups. The median immature granulocytes percentage was 0.4% in the endometrioma group, 0.3% in the haemorrhagic cyst group, 0.3% in the serous cystadenoma group, and 0.3% in the mucinous cystadenoma group. A statistically significant differences in the percentage of immature granulocytes were observed between the endometrioma group and the non-endometrioma group. CA-125 levels were significantly higher in the endometrioma group compared to the other groups. In ROC curve analysis, the area under the curve for immature granulocyte percentage was 0.645, with an optimal cutoff value of 0.3%, yielding 63.2% specificity and 64.5% sensitivity. Conclusion: The percentage of immature granulocytes may be used as a potential biomarker for predicting endometrioma in patients with benign ovarian cysts.