Non-functioning pituitary tumour after long-term treatment with gonadotrophin-releasing hormone agonists in a patient with vaginal agenesis who underwent neovaginoplasty and cauterization of endometriosis under laparoscopy: Case Report

Yasushi Takai, Y Takai, Takai Y, Osamu Tsutsumi, O Tsutsumi, Tsutsumi O, Momoeda M, M Momoeda, Mikio Momoeda, Yutaka Osuga, Osuga Y, Y Osuga, M Sadatsuki, Miyuki Sadatsuki, Sadatsuki M, Kaibara M, Manabu Kaibara, M Kaibara, Yuji Taketani, Y. Taketani, Taketani Y
Human Reproduction · 1999 · vol. 14(10) , pp. 2661–2664 · doi:10.1093/humrep/14.10.2661 · PMID:10528004 · W2120216420
article OA: bronze CC0 ⤵ 1 in-corpus citation
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

A patient with vaginal agenesis treated with long-term GnRH agonists developed a pituitary tumor that regressed after treatment cessation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Vaginal agenesis combined with a functional uterus is a rare condition in which treatment modalities that preserve reproductive function are controversial. A 21 year old female presented with congenital vaginal agenesis combined with cervical atresia. She was treated with gonadotrophin-releasing hormone (GnRH) agonists for a total period of over 5 years when a non-functioning pituitary tumour was detected by brain magnetic resonance imaging (MRI). A laparoscopically assisted reconstruction of a neovagina and neoendocervical canal was performed utilizing lyophilized porcine dermal skin to line the neovagina. Endometriosis of the pelvis was revealed and adhesiolysis and cauterization were also carried out under laparoscopy. The GnRH agonist was discontinued and the patient resumed cyclic menses with no abdominal pain. The pituitary tumour decreased in size 6 months after the cessation of GnRH agonists. We raise the question as to whether pituitary MRI should be performed for patients who need long-term administration of GnRH agonists.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Laparoscopy Pituitary Neoplasms Plastic Surgery Procedures Vagina Adult Brain Brain Cautery Endometriosis Female Gonadotropin-Releasing Hormone Humans Magnetic Resonance Imaging Pituitary Neoplasms Time Factors Vagina Vagina

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

Cited by (1)

References (19)

Cited by (1)

Source provenance

europepmc
last seen: 2026-08-20T06:14:21.026120+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:10:24.024533+00:00
License: CC0 · commercial use OK