The effect of diclofenac on uterine artery blood flow resistance during menstruation in patients with and without a copper intrauterine device

I Järvelä, Ilkka Y. Järvelä, A Tekay, Aydin Tekay, Pentti Jouppila, P Jouppila
Human Reproduction · 1998 · vol. 13(9) , pp. 2480–2483 · doi:10.1093/humrep/13.9.2480 · PMID:9806271 · W2152932965
Non-randomised trial OA: bronze CC0 ⤵ 1 in-corpus citation
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This study found diclofenac reduced uterine artery blood flow resistance during menstruation without an IUD but not with one, suggesting the IUD may induce non-prostaglandin vasoactive agents.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The aim was to evaluate the effect of diclofenac on uterine artery blood flow resistance during the first day of menstruation. A total of 28 regularly menstruating women were examined longitudinally with and without a copper intrauterine contraceptive device (IUD) by transvaginal colour Doppler ultrasonography. The uterine artery pulsatility index (PI) was first measured, after which 50 mg of diclofenac was infused i.v. After 15 min the PI was measured again. The patients evaluated their menstrual pain with a scoring system before and after the diclofenac infusion. The mean PI (SD) during menstruation was significantly lower with the IUD [2.13 (0.43)] than without [2.39 (0.62)], P = 0.05. The mean PI in nine patients who experienced advanced menstrual pain was also lower in the presence of the IUD [2.16 (0.42)] than without it [2.83 (0.78); P < 0.05]. Diclofenac was effective in revealing menstrual pain both with and without the IUD, and reduced the PI in the absence of an IUD [pre-treatment 2.39 (0.62) versus post-treatment 2.12 (0.45); P < 0.001], but had no effect when the IUD was present [pre-treatment 2.13 (0.43) versus post-treatment 2.10 (0.41)]. The results indicate that by inhibiting prostaglandin synthesis one can reduce the resistance to blood flow in the uterine arteries during menstruation. This does not hold true when an IUD is present, however, suggesting that the device might induce the production of vasoactive agents other than prostaglandins in the surrounding tissue.

My notes (saved in your browser only)

MeSH descriptors

Anti-Inflammatory Agents, Non-Steroidal Diclofenac Intrauterine Devices Intrauterine Devices Menstruation Uterus Vascular Resistance Adult Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Copper Diclofenac Diclofenac Female Humans Regional Blood Flow Regional Blood Flow Uterine Hemorrhage Uterine Hemorrhage Uterus

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

Cited by (1)

References (20)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T22:00:48.437354+00:00
License: CC0 · commercial use OK