Endometriosis and carcinosarcoma – a hypothetical correlation or a proven pathogenetic pathway? Colon carcinosarcoma with origin in endometriotic foci – a case report

Maria Szubert, Jacek Suzin, Paweł Stawerski, Katarzyna Kowalczyk-Amico, Markus Duechler
Ginekologia polska · 2015 · vol. 86(7) , pp. 547–550 · doi:10.17772/gp/58638 · PMID:26376535 · W2416828405
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This case report presents a postmenopausal woman with synchronous colon carcinosarcoma potentially originating from an endometriotic focus, supported by immunohistochemical markers common to both.

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Abstract

We present the first case of a patient with a synchronic occurrence of three neoplasms: non-small cell lung cancer serous cancer of the ovary and carcinosarcoma of the colon. Moreover, the possible origin of the carcinosarcoma is an endometriotic focus, which is an extremely rare occurrence, especially in women with no history of endometriotic treatment. Immunohistochemical staining of the carcinosarcoma was positive for CD10, estrogen receptors and desmin--typical markers for endometriotic foci. The growth of endometriosis depends on estrogen, which is produced at reduced levels after menopause. However, in some cases endometriosis could be diagnosed de novo in postmenopausal women. On the basis of the reported patient we discuss possible correlations between endometriosis and carcinosarcoma, as well as treatment methods of carcinosarcoma.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Carcinoma, Non-Small-Cell Lung Carcinosarcoma Colonic Neoplasms Endometriosis Lung Neoplasms Neoplasms, Multiple Primary Ovarian Neoplasms Precancerous Conditions Carcinoma, Non-Small-Cell Lung Carcinoma, Non-Small-Cell Lung Carcinoma, Non-Small-Cell Lung Carcinosarcoma Carcinosarcoma Carcinosarcoma Colonic Neoplasms Colonic Neoplasms Colonic Neoplasms Endometriosis Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (15)

Source provenance

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