Apport de l’étude immuno-histochimique dans les localisations intrathoraciques de l’endométriose : à propos de huit cas

Nathalie Guedj, Jean-Francois Côte, Jean‐François Côté, Côte JF, Lepimpec-Barthes F, Françoise Lepimpec-Barthes, Cécile Badoual, Carnot F, Francoise Carnot, Françoise Carnot, Marc Riquet, Riquet M, Danel C, Claire Danel
Annales de pathologie · 2009 · vol. 29(6) , pp. 475–480 · doi:10.1016/j.annpat.2009.10.024 · PMID:20005434 · W2043319183
article OA: closed CC0 ⤵ 2 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper presents an immunohistochemical analysis of eight cases to investigate intrathoracic endometriosis, a rare manifestation of the disease.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Thoracic endometriosis (TE) is rare with positive histological diagnosis sometimes difficult, particularly in atypical form. The aim of this study was to identify features which can increase performance of the histolological TE diagnosis and more particularly immuno-histochemical (IHC) contribution with hormonal receptors, smooth muscle actin, Ber-Ep4, CD10 and calretinin antibodies. To address this issue, we retrieved, retrospectively, a large series of 591 pneumothorax operated. Among them, 135 (23%) were females including eight (6%) cases related to TE. Those eight women were surgically treated with resection of pleura (n=6/8), lung (n=5/8) and diaphragmatic samples (n=6/8). Typical histological lesions of endometriosis were observed in six cases among eight. All diaphragmatic samples presented, macroscopically, holes responsible of thoraco-abdominal communication (n=6/6). Endometrial glands and/or endometrial stroma cells were found in the diaphragm (n=5/6) and in the pleura (n=2/6) but were never encountered in the lung (n=0/5). IHC study can confirm the five diaphragmatic localizations and can identify a new localization with expression of hormonal receptors, CD10 and smooth muscle actin in an island of fusiform cells. In conclusion, our study shows 1) the high frequency of diaphragmatic endometriosis localization which holes existence also can explain the pathogenesis, 2) the value of diaphragmatic samples in positive histological diagnosis of TE, 3) IHC interest to confirm endometriosis, particularly in atypical form and to differentiate from mesothelial cells inclusion.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Thoracic Diseases Thoracic Diseases Adult Autoantibodies Autoantibodies Autoantibodies Calbindin 2 Diaphragm Diaphragm Endometriosis Endometriosis Female Histocytochemistry Humans Immunohistochemistry Immunohistochemistry Middle Aged Nerve Tissue Proteins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

Cited by (2)

Source provenance

europepmc
last seen: 2026-08-12T06:07:16.479679+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:53.633898+00:00
unpaywall
last seen: 2026-08-12T06:43:03.944938+00:00
License: CC0 · commercial use OK