Effect of GnRH agonist therapy on the expression of human heat shock protein 70 in eutopic and ectopic endometria of women with endometriosis

This study investigated the role of heat shock protein 70 (HSP70) in endometriosis by analyzing its expression alongside CD68 in eutopic and ectopic endometrial tissues. Researchers utilized immunohistochemical methods to assess tissue samples from women with endometriosis, specifically examining pelvic peritoneal and ovarian lesions as well as normal uterine lining. The results demonstrated significantly enhanced HSP70 and CD68 expression in the eutopic endometrium and red peritoneal lesions compared to controls. Furthermore, treatment with GnRH agonists led to a significant reduction in HSP70 levels within the endometrium, indicating that this stress-related protein contributes to disease progression. This paper is centrally about endometriosis — specifically the molecular mechanisms involving HSP70 and their modulation by GnRH agonist therapy.

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