The potential role of HER2 upregulation in metastatic breast cancer to the uterus: a case report.

Moey MY, Hassan OA, Papageorgiou CN, Schnepp SL, Hoff JT
Clinical case reports · 2016 · doi:10.1002/ccr3.602 · PMID:27761241 · PMC5054465
OA: gold CC-BY-NC-ND-4.0
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Abstract

Abnormal uterine bleeding in a patient on maintenance hormonal therapy for breast cancer should raise concern for endometrial abnormalities including rare uterine metastasis from the breast. Hormonal receptor profile changes in metastatic lesions favoring human epidermal growth factor receptor 2 (HER2) overexpression may be involved in the pathogenesis of metastasis to the uterus.

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License: CC-BY-NC-ND-4.0