Complications of Assisted Reproductive Technology

- Frontmatter - Contents - Contributors - Foreword - Preface - Introduction - PART I PHYSIOLOGY OF REPRODUCTION - PART II INFERTILITY EVALUATION AND TREATMENT - PART III ASSISTED REPRODUCTION - 38 Medical Strategies to Improve ART Outcome: Current Evidence - 39 Surgical Preparation of the Patient for In Vitro Fertilization - 40 IVF in the Medically Complicated Patient - 41 Polycystic Ovary Syndrome and IVF - 42 Endometriosis and Assisted Reproductive Technology - 43 Evidence-Based Medicine Comparing hMG/FSH and Agonist/Antagonist and rec/Urinary hCG/LH/GnRH to Trigger Ovulation - 44 Luteal Phase Support in Assisted Reproduction - 45 Thrombophilia and Implanation Failure - 46 Intrauterine Insemination - 47 The Prediction and Management of Poor Responders in ART - 48 Oocyte Donation - 49 In Vitro Maturation of Human Oocytes - 50 Oocyte and Embryo Freezing - 51 Cryopreservation of Male Gametes - 52 The Management of Azoospermia - 53 Spermatid Injection: Current Status - 54 Optimizing Embryo Transfer - 55 Single Embryo Transfer - 56 Blastocyst Transfer - 57 Clinical Significance of Embryo Multinucleation - 58 Quality and Risk Management in the IVF Laboratory - 59 The Nurse and REI - 60 Understanding Factors That Influence the Assessment of Outcomes in Assisted Reproductive Technologies - 61 The Revolution of Assisted Reproductive Technologies: How Traditional Chinese Medicine Impacted Reproductive Outcomes in the Treatment of Infertile Couples - 62 Complications of Assisted Reproductive Technology - 63 Ectopic and Heterotopic Pregnancies Following in Vitro Fertilization - 64 The Impact of Oxidative Stress on Female Reproduction and ART: An Evidence-Based Review - 65 PGD for Chromosomal Anomalies - 66 Preimplantation Genetic Diagnosis for Single-Gene Disorders - 67 Epigenetics and ART - 68 Congenital Anomalies and Assisted Reproductive Technology - PART IV ETHICAL DILEMMAS IN FERTILITY AND ASSISTED REPRODUCTION - Index - Plate section - References from PART III - ASSISTED REPRODUCTION Published online by Cambridge University Press: 04 August 2010 Book contents - Frontmatter - Contents - Contributors - Foreword - Preface - Introduction - PART I PHYSIOLOGY OF REPRODUCTION - PART II INFERTILITY EVALUATION AND TREATMENT - PART III ASSISTED REPRODUCTION - 38 Medical Strategies to Improve ART Outcome: Current Evidence - 39 Surgical Preparation of the Patient for In Vitro Fertilization - 40 IVF in the Medically Complicated Patient - 41 Polycystic Ovary Syndrome and IVF - 42 Endometriosis and Assisted Reproductive Technology - 43 Evidence-Based Medicine Comparing hMG/FSH and Agonist/Antagonist and rec/Urinary hCG/LH/GnRH to Trigger Ovulation - 44 Luteal Phase Support in Assisted Reproduction - 45 Thrombophilia and Implanation Failure - 46 Intrauterine Insemination - 47 The Prediction and Management of Poor Responders in ART - 48 Oocyte Donation - 49 In Vitro Maturation of Human Oocytes - 50 Oocyte and Embryo Freezing - 51 Cryopreservation of Male Gametes - 52 The Management of Azoospermia - 53 Spermatid Injection: Current Status - 54 Optimizing Embryo Transfer - 55 Single Embryo Transfer - 56 Blastocyst Transfer - 57 Clinical Significance of Embryo Multinucleation - 58 Quality and Risk Management in the IVF Laboratory - 59 The Nurse and REI - 60 Understanding Factors That Influence the Assessment of Outcomes in Assisted Reproductive Technologies - 61 The Revolution of Assisted Reproductive Technologies: How Traditional Chinese Medicine Impacted Reproductive Outcomes in the Treatment of Infertile Couples - 62 Complications of Assisted Reproductive Technology - 63 Ectopic and Heterotopic Pregnancies Following in Vitro Fertilization - 64 The Impact of Oxidative Stress on Female Reproduction and ART: An Evidence-Based Review - 65 PGD for Chromosomal Anomalies - 66 Preimplantation Genetic Diagnosis for Single-Gene Disorders - 67 Epigenetics and ART - 68 Congenital Anomalies and Assisted Reproductive Technology - PART IV ETHICAL DILEMMAS IN FERTILITY AND ASSISTED REPRODUCTION - Index - Plate section - References To date nearly two million babies were born as a result of ART which is widely used all over the world for virtually all forms of infertility. The world collaboration report on ART, for the year 2000, included 460,000 in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles from forty-nine countries and total number of babies conceived through ART was between 197,000 and 220,000 (1). It is estimated that the figures in the world IVF report represent only approximately two-thirds of ART cycles performed in the world. The European registers on ART for the year 2002 by ESHRE reported 324,238 treatment cycles, which represented 12 percent increase since year 2001. In thirteen countries where all clinics reported to the register, a total of 177,429 cycles were performed in a population of 193.7 million, corresponding to 916 cycles per million inhabitants. The percentage of infants born after ART ranged from 1.3 to 4.2 percent of the total number of live births in the country (2). The long-term health consequences of this widely used technique have yet to be determined. At every stage of the procedure there is a potential for complications, some of which are dangerous and may be life threatening. Considering the magnitude and the continuous increase in the number of ART cycles IVF, ICSI performed every year, complications of ART is a worldwide iatrogenic health problem. - Type - Chapter - Information - Infertility and Assisted Reproduction , pp. 604 - 618Publisher: Cambridge University PressPrint publication year: 2008 World collaborative report on in vitro fertilization, 2000. Fertil Steril 2006;85:6:1586–1622.CrossRefGoogle ScholarPubMed , , , , , . Assisted reproductive technology in Europe, 2000. Results generated from European registers by ESHRE. Hum Reprod 2006;21:7:1680–1697.Google Scholar , , , , . Report of an ESHRE consensus meeting prepared. Risks and complications in assisted reproduction techniques. Hum Reprod 2003;18:2:455–457.CrossRefGoogle Scholar , . Complications of assisted reproductive techniques. A review. Assist Reprod 1999;9:4:214–232.Google Scholar , , , , . Clinical complications during in-vitro fertilization treatment. Hum Reprod 1992;7:625–626.CrossRefGoogle ScholarPubMed , . The incidence of major complications in a Dutch transport IVF programme. Hum Reprod Update 1996;2:345–353.CrossRefGoogle Scholar . , , et al. Complications of medically assisted conception in 3500 cycles. Fertil Steril 1998;70:638–642.CrossRefGoogle ScholarPubMed , , , et al. Short-term medical complications of 1500 Oocyte retrievals for in vitro fertilization and embryo transfer. Eur J Obstet Gynec and Reprod Biol 1998;239–243.CrossRefGoogle ScholarPubMed , , , , . , , , . , , . Anonymous reports of lethal cases of ovarian Hyperstimulation syndrome. In (Eds) , , . . Clinical manifestations of ovarian hyperstimulation syndrome. In (Eds) , , . Uterine and ovarian carcinoma in a patient receiving gonadotropin therapy: a case report. Obstet Gynecol 1982;89:962–964.Google Scholar , . Complications of assisted reproductive techniques. Fertil Steril 1994; 61:411–422.CrossRefGoogle ScholarPubMed , . , , . Epidemiology and etiology of ovarian cancer: a review. Obstet Gynecol 1985;66:127–135.Google ScholarPubMed , , . Ovarian neoplasis subfertility treatments. Br J Obstet Gynecol 1998;105:584–591.CrossRefGoogle Scholar , , , et al. . Prevention of ovarian cystomas by inhibition of ovulation: a new concept. J Reprod Med 1978;2:114.Google Scholar . The etiology and prevention of ovarian cancer. Am J Obstet Gynecol 1975;123:772–774.CrossRefGoogle ScholarPubMed . The epidemiology of ovarian cancer. Hematol Oncol Clin North Am 1992;6:729–738.CrossRefGoogle ScholarPubMed . Regulation of carcinogen metabolism in the rat ovary by the estrous cycle and gonadotropin. Science 1983;219:1437–1438.CrossRefGoogle ScholarPubMed , . Metabolism of 17,12-dimethyl-benz(a)anthracene by different types of cells in human ovary. Xenobiotica 1988;18:1255–1270.CrossRefGoogle Scholar , , . Cancer incidence in a cohort of infertile women. Am J Epidemiol 1987;125:780–790.CrossRefGoogle Scholar , , , et al. Population-based case-control study of ovarian cancer in Shanghai. Cancer Res 1989;49:3670–3674.Google ScholarPubMed , , , et al. The Collaborative Ovarian Cancer Group. Characteristics relating to ovarian cancer risk: collaborative analysis of 12 U.S. case-control studies. I. Methods. Am J Epidemiol 1992;136:1175–1183.CrossRefGoogle ScholarPubMed , , , et al. The Collaborative Ovarian Cancer Group. Characteristics relating to ovarian cancer risk: collaborative analysis of 12 U.S. case-control studies. II. Invasive epithelial ovarian cancers in white women. Am J Epidemiol 1992;136:1184–1203.CrossRefGoogle ScholarPubMed , , . The Collaborative Ovarian Cancer Group. Characteristics relating to ovarian cancer risk: collaborative analysis of 12 U.S. Case-control studies. III. Epithelial tumors of low malignant potential in white women. Am J Epidemiol 1992;136:1204–1211.CrossRefGoogle ScholarPubMed , , . , , , et al. Human menopausal gonadotropin and the risk of epithelial ovarian cancer. Fertil Steril 1996;65:13–18.CrossRefGoogle ScholarPubMed , , , et al. Breast and ovarian cancer incidence after infertility and in vitro fertilization. Lancet 1995; 346:995–1000.CrossRefGoogle Scholar , , , et al. treatment for infertility and risk of invasive epithelial cancer. Hum Reprod 1997; 12:2159–2161.CrossRefGoogle Scholar , , , et al. Infertility, fertility drugs, and invasive ovarian cancer: a case-control study. Fertil Steril 1997;67:1005–1012.CrossRefGoogle ScholarPubMed , , , et al. Cancer risk associated with subfertility and ovulation induction: a review. Cancer Causes Control 2000;11:319–344.CrossRefGoogle ScholarPubMed , , , . Induction of ovulation and ovarian cancer: A critical review of the literature. Fertil Steril 2006;85:4:819–826.CrossRefGoogle ScholarPubMed , , . Fertility treatment and risk of breast cancer. Hum Reprod 1996;11:300–303.CrossRefGoogle ScholarPubMed , , , et al. Risk of cancer after use of fertility drugs with in vitro fertilization. Lancet 1999;354:1586–1590.CrossRefGoogle Scholar , , , , . Breast cancer risk associated with ovulation stimulation drugs. Hum Reprod 2004;19(9):2005–2013.CrossRefGoogle Scholar , , , , , , . , , , et al. Choriocarcinoma of the fallopian tube associated with induced superovulation in an IVF program: a case report. Eur J Obstet Gynecol Reprod Biol 1989;33:183–186.CrossRefGoogle Scholar , , , et al. Adverse local reaction to intramuscular injections of urinary-derived gonadotrophins. Hum Reprod 1993; 8:1835–1836.CrossRefGoogle ScholarPubMed , . Hypersensitization to human menopausal gonadotropins with anaphylactic shock syndrome during a fifth in vitro fertilization cycle. J Assist Reprod Genet 1994;11:51–53.CrossRefGoogle ScholarPubMed , , , et al. Delayed-type hypersensitivity to human gonadotropin: case report. Fertil Steril 1995;64:855–856.CrossRefGoogle ScholarPubMed , , , et al. Optic neuropathy associated with clomiphene citrate therapy. Fertil Steril 1994;61:390–391.CrossRefGoogle ScholarPubMed . Initial presentation of undiagnosed acute intermittent porphyria as a rare complication of ovulation induction. Fertil Steril 2006; 86:2:462–e1–e3.CrossRefGoogle ScholarPubMed , , , , . Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet 1976;1:880–882.CrossRefGoogle ScholarPubMed , . Transvaginal sonographically controlled ovarian follicle puncture for egg retrieval. Lancet 1984;1:1467.CrossRefGoogle ScholarPubMed , , , et al. Laparoscopic or ultrasonically guided follicle aspiration for in vitro fertilization?J In Vitro Fertil Embryo Transfer 1984;1:244–249.CrossRefGoogle ScholarPubMed , . Perioperative and postoperative complications transvaginal ultrasound-guided oocyte retrieval. Prospective of study of >1000 oocyte retrievals. Hum Reprod 2006;21:12:3235–3240.CrossRefGoogle ScholarPubMed , , , , . Pelvic infection after transvaginal ultrasound-guided ovum retrieval. Fertil Steril 1988;49:726–728.CrossRefGoogle ScholarPubMed , , , et al. Complications of transvaginal ultrasound-directed follicle aspiration. A review of 2670 consecutive procedures. J Assist Reprod Genet 1993;10:72–77.CrossRefGoogle Scholar , , , et al. Uterine abscess after ultrasound guided ovum retrieval in an in vitro fertilization-embryo transfer program: case report and review of the literature. J Assist Reprod Genet 1992;9:285–289.CrossRefGoogle Scholar , , . Acute abdomen following dermoid cyst rupture during transvaginal ultrasonographically guided retrieval of oocytes. Hum Reprod 1996;11:1897–1899.CrossRefGoogle ScholarPubMed , , , et al. Traumatic ureteric obstruction secondary to oocyte recovery for in vitro fertilization: a case report. J In Vitro Fertil Embryo Transfer 1989;6:186–187.CrossRefGoogle ScholarPubMed , , , et al. Ureteral obstruction: a complication of oocyte retrieval. Fertil Steril 1994;61:787 (Letter).CrossRefGoogle ScholarPubMed , , . Ureteral lesion secondary to vaginal ultrasound follicular puncture for oocyte recovery in in-vitro fertilization. Hum Reprod 1997; 12:948–950.CrossRefGoogle ScholarPubMed , , , et al. Acute ureteral obstruction following transvaginal oocyte retrieval for IVF. Hum Reprod 2002;17:1:137–138.CrossRefGoogle ScholarPubMed , , , . Rectus sheath hematoma after transvaginal follicle aspiration: a rare complication of in vitro fertilization. Fertil Steril 2005;84(1):217.e1–e3.CrossRefGoogle ScholarPubMed , , , . Severe bradycardia and bradypnea following vaginal oocyte retrieval: a possible toxic effect of paracervical mepivacaine. Eur J Obstet Gynaecol Reprod Biol 2000;91:71–73.CrossRefGoogle ScholarPubMed , , , , . Massive retroperitoneal bleeding: a complication of transvaginal ultrasonography-guided oocyte retrieval for in vitro fertilization-embryo transfer. Fertil Steril 2000;74:2:405–406.CrossRefGoogle ScholarPubMed , , , , , . Vaginal perforation during transvaginal ultrasound-guided follicle aspiration in a woman undergoing multiple cycles of assisted reproduction. Fertil Steril 2004;81(6):1695–1696.CrossRefGoogle Scholar , , . Vertebral osteomyelitis: a rare complication of transvaginal ultrasound-guided oocyte retrieval. Fertil Steril 2000;73(6):1250–1252.CrossRefGoogle ScholarPubMed , , , , , . Anaphylactic reaction to bovine serum albumin after embryo transfer. Fertil Steril 1998;70:4:771–773.CrossRefGoogle ScholarPubMed , , , , , . Impact of reproductive history on in vitro fertilization and intracytoplasmic sperm injection outcome: evidence from the German IVF Registry. Fertil Steril 2003;80:508–516.CrossRefGoogle ScholarPubMed , , , , . Spontaneous abortion among pregnancies conceived using assisted reproductive technology in the United States. Obstet Gynecol 2003;101:959–967.Google ScholarPubMed , , , , . Incidence of spontaneous abortion among pregnancies produced by assisted reproductive technology. Hum Reprod 2004;19:272–277.CrossRefGoogle ScholarPubMed , , . Assist Reproductive Technology Series. Number 8. Publication of AIHW National Perinatal Statistics Unit, no. PER 26, Sydney, Australia, 2004.Google Scholar , , . Supplement to assisted reproductive technology in Australia and New Zealand. Risk factors for ectopic pregnancy in 556 pregnancies after in vitro fertilization: implications for preventive management. Fertil Steril 1991; 56:686–690.CrossRefGoogle ScholarPubMed , , , et al. Ectopic pregnancy following IVF/ICSI-ET in the United Kingdom, HFEA Register (1991–1999). Abstracts of the 19th Annual meeting of ESHRE, Madrid, Spain, 2003:xviii34–xviii35.Google Scholar , , , . Risk factors for ectopic pregnancy after in vitro fertilization and embryo transfer. J Assist Reprod Genet 1995;12:594–598.CrossRefGoogle Scholar , , , et al. Cornual pregnancies in patients with prior salpingectomy undergoing in vitro fertilization and embryo transfer. Fertil Steril 1996;65:659–660.CrossRefGoogle ScholarPubMed , , , et al. Uterine rupture in first or second trimester of pregnancy after in vitro fertilization and embryo transfer. Hum Reprod 1996;11:1120–1122.CrossRefGoogle ScholarPubMed , , , et al. The prediction of ectopic pregnancy after in vitro fertilization and embryo transfer. Hum Reprod 1995;10:2165–2168.CrossRefGoogle ScholarPubMed , , . Diagnosis of ectopic pregnancy after in vitro fertilization and embryo transfer. Fertil Steril 1997;68:1027–1032.CrossRefGoogle ScholarPubMed , , , et al. Heterotopic pregnancy after IVF-ET: report of a case and a review of the literature. Hum Reprod 1989;4:335–336.CrossRefGoogle Scholar , , , et al. Simultaneous intrauterine and extrauterine pregnancy. Am J Obstet Gynecol 1948;56:1119–1123.Google Scholar , . Heterotopic pregnancy after ovulation induction and assisted reproductive technologies: a literature review from 1971 to 1993. Fertil Steril 1996; 66:1–12.Google ScholarPubMed , , , et al. Danish National IVF Registry 1994 and 1995. Treatment pregnancy outcome and complications during pregnancy. Acta Obstet Gynecol Scand 2000;79:384–389.CrossRefGoogle ScholarPubMed , , , . Transferring more embryos increases risk of heterotopic pregnancy. Fertil Steril 1994;61:1065–1067.CrossRefGoogle ScholarPubMed , , , et al. Simultaneous bilateral tubal pregnancy following in vitro-fertilization and embryo transfer. Hum Reprod 1998;13:465–467.CrossRefGoogle ScholarPubMed , , . Bilateral simultaneous tubal sextuples: pregnancy after in-vitro fertilization- embryo transfer following salpingectomy. Hum Reprod 1998;13:762–765.CrossRefGoogle Scholar , , , et al. Assisted reproduction technologies: estimates of their contribution to multiple births and newborn hospital days in the United States. Fertil Steril 1996;65:361–366.CrossRefGoogle ScholarPubMed , , , et al. Outcome of twin, triple and quadruplet in in-vitro fertilization pregnancies: the Nor Folk experience. Fertil Steril 1992;57:825–834.CrossRefGoogle Scholar , , , . Incidence of handicaps in multiple births and associated factors. Acta Genet Med Gemellol 1995;44:81–91.CrossRefGoogle ScholarPubMed , , . Deliveries and children born after in-vitro fertilization in Sweden 1982-95: a retrospective cohort study. Lancet 1999;354:1579–1585.CrossRefGoogle ScholarPubMed , , , et al. Elective single-embryo transfer. Has its time arrived?N Engl J Med 2004;351:2440.CrossRefGoogle ScholarPubMed . Attitudes of in vitro fertilization and intrauterine insemination couples towards multiple gestation pregnancy and multifetal pregnancy reduction. Fertil Steril 1996;65:815–820.CrossRefGoogle Scholar , , , . ESHRE Campus Report. Prevention of twin pregnancies after IVF/ICSI by single embryo transfer. Hum Reprod 2001;16:4:790–800. Current practices and controversies in assisted reproduction. WHO Report of a meeting on Medical, Ethical and Social Aspects of Assisted Reproduction 17–21 September 2001. WHO, 2002, Geneva.Google Scholar , , . Avoiding multiple pregnancies in ART. Replace as many embryos as you like – one at a time. Hum Reprod 2000;15:8:1662–1665.CrossRefGoogle ScholarPubMed . A prediction model for selecting patients undergoing in vitro fertilization for elective single embryo transfer. Fertil Steril 2002;77(4):725–732.CrossRefGoogle ScholarPubMed , , , , , , . Number of embryos for transfer following in-vitro fertilization or intracytoplasmic sperm injection. Cochrane Review 25/8/2004. Human Reprod 2005;20(10):2681–2687.Google Scholar , , , , . Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on strict embryo criteria: a prospective randomized clinical trial. Hum Reprod 1999;14:2581–2587.CrossRefGoogle ScholarPubMed , , , et al. One versus two embryo transfer after IVF and ICSI: a randomised study. Hum Reprod 2001;16(9):1900–1903.CrossRefGoogle Scholar , , , et al. Elective single embryo transfer: the value of cryopreservation. Hum Reprod 2001;16(6):1140–1144.CrossRefGoogle ScholarPubMed , , . Elective single embryo transfer versus double-embryo transfer in vitro fertilization. N Engl J Med 2004;351:2392.CrossRefGoogle ScholarPubMed , et al. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ 2004;328:261–265.CrossRefGoogle ScholarPubMed , , , . Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 2004;103:551–563.CrossRefGoogle ScholarPubMed , , , . Assessment of separate contributions to perinatal mortality of infertility history and treatment: a case-control analysis. Lancet 1999;353:1746–1749.CrossRefGoogle ScholarPubMed , , , . Does subfertility explain the risk of poor perinatal outcome after IVF and ovarian hyperstimulation?Hum Reprod 2006;21(12):3228–3234.CrossRefGoogle ScholarPubMed , , , , , , . , , , , , . UCSF, San Francisco, CA. The obstetrical and neonatal outcome of babies born after single-embryo transfer in IVF/ICSI compares favourably to spontaneously conceived babies. Hum Reprod 2006;21(4):1041–1046.CrossRefGoogle ScholarPubMed , , , , , , . WHO. Recent advances in medically assisted conception. Report of WHO Scientific Group (Co-Rapporteur) Geneva (820). 1992. Experience with the elective transfer of two embryos under the conditions of the German embryo protection law: results of a retrospective data analysis of 2573 transfer cycles. Hum Repord 2000;1(5):319–324.CrossRefGoogle Scholar , , , et al. Multiple pregnancy. An ongoing epidemic. What can we do about it?Egyptian J Fertil Steril 2006;10(2):1–4.Google Scholar . FIGO Ethics Committee guidelines. Ethical recommendations on multiple pregnancy and multifetal reduction. Int J Gynecol Obstet 2006;92(3):331–332.CrossRef First trimester bleeding in clinical IVF pregnancies. Hum Reprod 1988;3:807–809.CrossRefGoogle ScholarPubMed , , , , , . Vaginal bleeding and early pregnancy outcome in an infertile population. J Assist Reprod Genet 1996;13:212–215.CrossRefGoogle Scholar , , , , , . Frequency and effect of vaginal bleeding in pregnancy outcome during the first 3 weeks after positive B-hCG test results following IVF-ET. Fertil Steril 2000;74:609–610.CrossRefGoogle Scholar , , , . Bleeding and spontaneous abortion after therapy for infertility. Fertil Steril 2000;74:504–508.CrossRefGoogle ScholarPubMed , , , , . Incidence and outcome of bleeding before the 20th week of pregnancy: prospective study from general practice. BMJ 1997;315:32.CrossRefGoogle ScholarPubMed . First-trimester bleeding and pregnancy outcome in singletons after assisted reproduction. Hum Reprod 2006; 21(7):1907–1911.CrossRefGoogle ScholarPubMed , , , , , . Maternal and neonatal morbidity associated with in vitro fertilization. J Pediatr 1995;127(5):794–800.CrossRefGoogle ScholarPubMed , , , , , . Increased risk of placenta previa in pregnancies following IVF/ICSI; a comparison of ART and non-ART pregnancies in the same mother. Hum Reprod 2006;21(9):2353–2358.CrossRefGoogle ScholarPubMed , , , , , . Obstetric outcome of in vitro fertilization pregnancies compared with normally conceived pregnancies. Am J Obstet Gynecol 1992;167:778–784.CrossRefGoogle ScholarPubMed , , , et al. The obstetric outcome of assisted conception treatment. Assist Reprod Rev 1992;2:116–125.Google Scholar , . Maternal and neonatal morbidity associated with in vitro fertilization. J Pediatr 1995;127:794–800.CrossRefGoogle ScholarPubMed , , , et al. The increased risk of complication observed in singleton pregnancies resulting from in-vitro fertilization (IVF) does not seem to be related to the IVF method itself. Hum Reprod 1993;8:1297–1300.CrossRefGoogle ScholarPubMed , , , et al. Obstetric outcome in singleton pregnancies after assisted reproduction. Obstet Gynecol 1995;86:188–192.CrossRefGoogle ScholarPubMed , , , et al. Is the obstetric outcome of in vitro fertilize singleton gestation different from nature ones? A controlled study. Fertil Steril 1997;67:1077–1083.CrossRefGoogle Scholar , , , et al. Obstetric outcome of singleton pregnancies conceived by in vitro fertilization and ovulation induction compared with those conceived spontaneously. Fertil Steril 1998;70:240–245.CrossRefGoogle ScholarPubMed , , , et al. International Working Group for Registers on Assisted Reproduction: World Collaborative Report on In Vitro Fertilization Preliminary data for 1995. J Assist Reprod Genet 1997;14 (Suppl):251S–265S.Google Scholar , . Report of the Working Party on Children Conceived by In Vitro Fertilization. Births in Great Britain Resulting from Assisted Conception, 1978–87. BMJ 1990;300:1229–1233. Preterm delivery, low birth weight and small-for-gestational-age in liveborn singleton babies resulting from in vitro fertilization. Hum Reprod 1992;7:425–428.CrossRefGoogle ScholarPubMed , , . Task force report on the outcome of pregnancies and children conceived by in vitro fertilization (France: 1987 to 1989). Fertil Steril 1994;61:324–330.CrossRefGoogle Scholar , , , et al. FIVNAT (French in Vitro National). Pregnancies and births resulting from in vitro fertilization: French national registry, analysis of data 1986 to 1990. Fertil Steril 1995;64:746–756.CrossRef Perinatal outcome of pregnancies after assisted reproduction: a case-control study. J Assist Reprod Genet 1997;14:575–580.CrossRefGoogle Scholar , , et al. Impact of infertility treatments on the health of newborns. Fertil Steril 1998:69:210–215.CrossRefGoogle ScholarPubMed , , , et al. Morbidity in a Danish National cohort of 472 IVF/ICSI twins, 1132 non-IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social implications for the children and their families. Hum Reprod 2003;18:6:1234–1243.CrossRefGoogle Scholar , , , . Neonatal outcome in a Danish national cohort of 3438 IVF/ICSI and 10 362 non-IVF/ICSI twins born between 1995 and 2000. Hum Reprod 2004; 19:2:435–441.CrossRefGoogle Scholar , , , , , , . Obstetric and perinatal outcome and preliminary results of development of children born after in vitro maturation of oocytes. Hum Reprod 2006;21(6):1508–1513.CrossRefGoogle ScholarPubMed , , , , . Clustering of male factor infertility in the families of couples treated with intra cytoplasmic sperm injection. Hum Reprod 2000;15:1604–1608.CrossRefGoogle Scholar , , , , , . Delivery and children born after in vitro fertilization in Sweden 1982-1995. A retrospective cohort study. Lancet 1999;1579–1585.CrossRefGoogle Scholar , , , et al. Congenital malformations in infants born after IVF: a population-based study. Hum Reprod 2001;16:504–509.CrossRefGoogle ScholarPubMed , . Neonatal outcome and congenital malformations in children born after in-vitro fertilization. Hum Reprod 2002;17:5:1391–1398.CrossRefGoogle ScholarPubMed , , , , , . The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med 2002;346:725–730.CrossRefGoogle Scholar , , , . Neonatal Data on a cohort of 2889 infants born after ICSI (1991–1999) and of 2995 infants born after IVF (1983–1999). Hum Reprod 2002;17:671–694.CrossRefGoogle Scholar , , , , , , . Incidence of congenital malformation in children born after ICSI. Hum Reprod 2000;15:944–948.CrossRefGoogle ScholarPubMed , , , , , , . Prenatal testing in ICSI pregnancies: incidence of chromosomal anomalies in 1586 karyotypes and relation to sperm parameters. Hum Reprod 2002; 17:2600–2614.CrossRefGoogle ScholarPubMed , , , , , , . Frequency of hyper-hypohaploidy and diploidy in ejaculated, epididymal and testicular germ cells of infertile patients. Hum Reprod 2000;15:2165–2172.CrossRefGoogle ScholarPubMed , , , , , , , , , . Outcome of pregnancies after intracytoplasmic sperm injection and the effect of sperm origin and quality on this outcome. Fertil Steril 1998;70:5000–5005.CrossRefGoogle ScholarPubMed , , , , , . Sperm chromosome abnormalities in men with severe male factor infertility who are undergoing in vitro fertilization with intracytoplasmic sperm injection. Fertil Steril 2001; 76:479–484.CrossRefGoogle ScholarPubMed , , , , , . FISH analysis of chromosome X, Y and 18 abnormalities in testicular sperm from azoospermic patients. Hum Reprod 2002;17:2249–2257.CrossRefGoogle Scholar , , , , , . Chromosome analysis of spermatozoa extracted from tests of men with non-obstructive azoospermia. Hum Reprod 2000; 15:1121–1124.CrossRefGoogle Scholar , , , , , . Obstetric outcome of pregnancies following ICSI, classified according to sperm origin and quality. Hum Reprod 2000;15:1189–1194.CrossRefGoogle ScholarPubMed , , , , , . Malformation rate in fetuses and children conceived after ICSI: results of a prospective cohort study. Reprod Biomed Online 2002;5:171–178.CrossRefGoogle ScholarPubMed , . Pregnancy outcome and neonatal data of children born after ICSI using testicular sperm in obstructive and non-obstructive azoospermia. Hum Reprod 2003;18(10):2093–2097.CrossRefGoogle ScholarPubMed , , , , , . Panel reviews health effects data for assisted reproductive technologies. J Am Med Assoc 2004;292(24):2961–2962.Google Scholar . Epigenetic risks related to assisted reproductive technologies: epigenetics, imprinting, ART and icebergs?Hum Reprod 2003;18(12):2508–2511.CrossRefGoogle ScholarPubMed , , . Minor congenital anomalies, major congenital malformations and development in children conceived from cryopreserved embryos. Hum Reprod 1995;10:3332–3337.CrossRefGoogle Scholar , , , et al. Perinatal outcome and follow up of 82 children aged 1–9 years old conceived from cryopreserved embryos. Hum Reprod 1996;11:1565–1568.CrossRefGoogle ScholarPubMed , , , et al. Obstetric and perinatal outcome of children conceived from cryopreserved embryos. Hum Reprod 1997;12:1819–1825.CrossRefGoogle ScholarPubMed , , , et al. Cryotop vetrification of human oocytes results in high survival rate and healthy deliveries. RBM Online 2007;14(1):72–79.Google ScholarPubMed , , , , , . Incidence of birth details after artificial insemination with frozen donor spermatozoa: a collaborative study of the French CECOS Federation on 11.535 pregnancies. Hum Reprod 1996;11:2319–2323.CrossRefGoogle Scholar , , , et al. Emotional factors and the in vitro fertilization and embryo transfer process. J In Vitro Fertil Embryo Transfer 1987;4:232–236.CrossRefGoogle ScholarPubMed , , . Psychosocial adjustment following unsuccessful in vitro fertilization. J Psychosom Obstet Gynaecol 1988;9:181–190.CrossRefGoogle Scholar , , , et al. Psychological assessment and follow up after in vitro fertilization: assessing the impact of failure. Fertil Steril 1990;54:879–886.CrossRefGoogle Scholar , , . A prospective, longitudinal study of emotions and relationships in vitro fertilization treatment. Hum Reprod 1997;12:183–190.CrossRefGoogle ScholarPubMed , , . In-vitro fertilization the experience of treatment, pregnancy and delivery. Hum Reprod 1996;11:95–98.CrossRefGoogle Scholar , , . Impact of the in-vitro fertilization process on emotional, physical and relational variables. Hum Reprod 1996;11:903–907.CrossRefGoogle ScholarPubMed , . Parenting and psychological development of IVF children: a follow up study. Hum Reprod 2002; 17(4):1116–1123.CrossRefGoogle ScholarPubMed , . Assessment at one year of the psychological consequences of having triplets. Hum Reprod 1992;7:729–732.CrossRefGoogle ScholarPubMed , . Psychological consequences of having triplets: a 4 year follow-up study. Fertil Steril 1997; 67:1162–1165.CrossRefGoogle ScholarPubMed , , . The economic impact of multiple-gestation pregnancies and the contribution of assisted-reproduction techniques to their incidence. N Engl J Med 1994;331:244–249.CrossRefGoogle ScholarPubMed , , , et al. Cost-effectiveness of in vitro fertilization. Obstet Gynecol 1996;87:18–21.CrossRefGoogle ScholarPubMed , , , et al. The cost of a successful delivery with in vitro fertilization. N Engl J Med 1994; 331:239–243.CrossRefGoogle ScholarPubMed , , . In vitro fertilization and embryo transfer in Egypt. Int J Obstet Gynaecol 1991;36:49–53.CrossRefGoogle ScholarPubMed , , . 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