Relative bioavailability of danazol in dogs from liquid-filled hard gelatin capsules
Lab / animal
OA: closed
CC0
⤵ 12 in-corpus citations
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This study evaluated the relative bioavailability of danazol in dogs following administration via liquid-filled hard gelatin capsules.
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Abstract
Danazol was dissolved in non-aqueous mixtures containing either polyethylene glycol 400 or polysorbate 80, and filled into hard gelatin capsules at 50 mg concentrations. The bioavailability of these formulations was compared with commercial danazol capsules in a two-way crossover study using young female beagle dogs. Both formulations showed greater oral bioavailability when compared with either the 100 or 200 mg commercial brand of danazol. The bioavailability of the polyethylene glycol 400 and polysorbate 80 formulations was enhanced 3.7 and 15.8 times, respectively, when compared at the 100 mg dose level.
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References (10)
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- Surface treatment of the hydrophobic drug danazol to improve drug dissolution via openalex
- Vaginal patterns during danazol and buserelin acetate therapy for endometriosis: structural and ultrastructural study via openalex
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Cited by (10)
- Danazol 2022
- Danazol oral absorption modelling in the fasted dog: An example of mechanistic understanding of formulation effects on drug pharmacokinetics 2019
- Optimization of PEGylated nanoemulsions for improved pharmacokinetics of BCS class II compounds 2013
- Evaluation of a nanoemulsion formulation strategy for oral bioavailability enhancement of danazol in rats and dogs 2013
- Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability 2013
- Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs 2007
- Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs 2007
- Supersaturation produces high bioavailability of amorphous danazol particles formed by evaporative precipitation into aqueous solution and spray freezing into liquid technologies 2006
- Supersaturation produces high bioavailability of amorphous danazol particles formed by evaporative precipitation into aqueous solution and spray freezing into liquid technologies 2006
- Rapid release tablet formulation of micronized danazol powder produced by spray-freezing into liquid (SFL) 2004
Source provenance
- openalex
- last seen: 2026-05-11T06:27:45.971503+00:00
- pubmed
- last seen: 2026-10-08T20:58:50.057178+00:00
- unpaywall
- last seen: 2026-10-13T06:25:51.201866+00:00
License: CC0
· commercial use OK