Effect of danefukang on symptoms and biomarkers in women with endometriosis

Yi-cun Zhong, Xiaofei Zhou, Xiao-Fei Zhou, Chunmei Hou, Chun-Mei Hou, Weiping Li, Wei-Ping Li
Taiwanese journal of obstetrics & gynecology · 2019 · vol. 58(2) , pp. 218–222 · doi:10.1016/j.tjog.2019.01.009 · PMID:30910142 · W2943962155
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Abstract

OBJECTIVE: The purpose of this study was to observe the efficacy of Danefukang (DEFK) soft extract for the treatment of symptoms associated with endometriosis, and its effect on quality of life, the Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) scores, and on levels of carbohydrate antigen (CA)-125, tumor necrosis factor (TNF)-α, and interleukin (IL)-6. MATERIALS AND METHODS: A total of 174 patients with endometriosis treated from January 2010 to December 2013 were randomly divided into a control group treated with mifepristone (n = 87) or DEFK (n = 87). Both groups were treated for 3 months. Symptoms, quality of life, SAS, SD scores, and levels of CA-125, TNF-α, and IL-6 were evaluated before and after treatment. RESULTS: = 4.215, P < 0.05). Treatment with DEFK resulted in a greater improvement in quality of life, SDS, and SAS scores compared with mifepristone (all, P < 0.05). DEFK treatment also resulted in a greater decrease of CA-125, TNF-α, and IL-6 levels compared with mifepristone (all, P < 0.05). CONCLUSION: Based on the current results - improved symptoms, attenuated depression and anxiety, and reduced the levels of pro-inflammatory cytokines and CA-125 -treatment with DEFK is a meaningful option for patients with endometriosis. DEFK fills an unmet need in the pharmacologic treatment of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Drugs, Chinese Herbal Endometriosis Quality of Life Anxiety Anxiety Anxiety Biomarkers Biomarkers CA-125 Antigen CA-125 Antigen Case-Control Studies Depression Depression Depression Drugs, Chinese Herbal Endometriosis Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female

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