Effect of danazol on estrogen-and progesterone-receptor systems of the human endometrium

L.V. Adamyan; М. Л. Алексеева; Н. Н. Жукова; L S Minina; Е. А. Новиков

doi:10.1007/bf00835688

Effect of danazol on estrogen-and progesterone-receptor systems of the human endometrium

L.V. Adamyan, М. Л. Алексеева, Н. Н. Жукова, L S Minina, Е. А. Новиков

In: Bulletin of Experimental Biology and Medicine · 1988 · vol. 105(2) , pp. 184–185 · doi:10.1007/bf00835688 · PMID:3349148 · W2410772565

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This abstract describes the suppressive effects of blast cells on mouse splenocytes and immune responses, suggesting a link to leukemia pathogenesis, rather than addressing endometriosis or adenomyosis.

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Abstract

Blast cells obtained from the "erythropoietic spleen" of FG-stimulated young mice and cells accumulating in the spleens of preleukemic AKR mice have a marked suppressive effect on spontaneous and mitogen-induced proliferation of young mouse splenocytes in vitro and suppress the development of humoral immune response in immunized recipients during syngeneic transfer in vivo. Some disturbances in erythron system in preleukemic AKR mice manifested in the accumulation of immature erythroid precursors which are suppressors of immunocompetent lymphocytes are suggested to be a pathogenetic link in the development of leukemia.

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References (6)

In vitro effect of danazol on steroidogenesis in developing human follicles via openalex
Short‐term effects of danazol on endometrial histology via openalex
Steroidal regulation of endometriosis tissue: lack of induction of 17β-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol via openalex
doi:10.1042/bj1260561 via openalex
doi:10.1016/0022-4731(76)90034-0 via openalex
doi:10.1016/s0015-0282(16)43869-0 via openalex

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[1] Steroidal regulation of endometriosis tissue: lack of induction of 17β-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol 1985

[2] Short‐term effects of danazol on endometrial histology 1984

[3] In vitro effect of danazol on steroidogenesis in developing human follicles 1984